. " "@en . . . . "For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis."@en . . . "Pralidoxime"@en . . "Pralidoximum"@en . "approved"@en . . . . . . . . "Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. Acetylcholinesterase inhibition causes acetylcholine to accumulate in synapses, producing continuous stimulation of cholinergic fibers throughout the nervous systems. If given within 24 hours after organophosphate exposure, pralidoxime reactivates the acetylcholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase."@en . . . "Pralidoxime"@en . . . "2-PAM"@en . "The drug is rapidly excreted in the urine partly unchanged, and partly as a metabolite produced by the liver."@en . . . . "Pralidoxim"@en . . . "6735-59-7"@en . . " "@en . . . . . . . . . . "74-77 minutes"@en . "Pralidoxima"@en . "No binding to plasma proteins"@en . . . "Humans and other mammals"@en . . . . . . . . . . . . . . "Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase."@en . . . .