. . . . . "Ergotaminum"@en . . . . . . "approved"@en . . "Humans and other mammals"@en . . . . . . . . . . . . . "Ergotamin"@en . . . . . . . . . . . . . "2 hours"@en . . . . . . . . . . . . . . . . . . . . . . . . . "Caffeine increases absorption."@en . "Ergotamine acts on migraine by one of two proposed mechanisms: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache, and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release."@en . . . . "(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione"@en . . . "A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. [PubChem]"@en . . "Take without regard to meals."@en . "Signs of overexposure include irritation, nausea, vomiting, headache, diarrhea, thirst, coldness of skin, pruritus, weak pulse, numbness, tingling of extremities, and confusion."@en . . . . "113-15-5"@en . . . . . . "Gynergen"@en . . "# Tfelt-Hansen P, Saxena PR, Dahlof C, Pascual J, Lainez M, Henry P, Diener H, Schoenen J, Ferrari MD, Goadsby PJ: Ergotamine in the acute treatment of migraine: a review and European consensus. Brain. 2000 Jan;123 ( Pt 1):9-18. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10611116 # Schardl CL, Panaccione DG, Tudzynski P: Ergot alkaloids--biology and molecular biology. Alkaloids Chem Biol. 2006;63:45-86. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17133714"@en . . . . "Ergotamine"@en . "Ergotamina"@en . . . . . . . . . "Ergotamine"@en . " "@en . "12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione"@en . "For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called \"histaminic cephalalgia\"."@en . "The bioavailability of sublingually administered ergotamine has not been determined."@en . . . .