. "147059-72-1"@en . . . "For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis."@en . . "Trovafloxacin is a fluoronaphthyridone related to the fluoroquinolones with in vitro activity against a wide range of gram-negative and gram-positive aerobic and anaerobic microorganisms. The bactericidal action of trovafloxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription, and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division."@en . . "withdrawn"@en . . "Trovafloxacin"@en . " "@en . . . . . "Well-absorbed from the gastrointestinal tract after oral administration and does not depend on concomitant food intake. The absolute bioavailability is approximately 88%."@en . . " "@en . . . . . . . . . "The mean plasma protein bound fraction is approximately 76%, and is concentration-independent."@en . "Trovafloxacin (sold as Trovan by Pfizer) is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones. [Wikipedia]"@en . "Approximately 50% of an oral dose is excreted unchanged (43% in the feces and 6% in the urine)."@en . . . . . . . . "Following oral administration, half-life ranged from 9.1 hours to 12.2 hours over the dosage range of 100 to 200 mg tablets. Following intravenous infusion, half-life ranged from 9.4 to 12.7 hours over a dosage range of 100 to 300 mg."@en . "approved"@en . . . . . . . . . . . . . . . . . "Symptoms of overdose include convulsions, decreased activity, diarrhea, sleepiness, tremors, and/or vomiting."@en . . . . . . "Enteric bacteria and other eubacteria"@en . . . . .