"115-67-3"@en . "Paramethadione"@en . . . "Paramethadione"@en . . "Not significant"@en . . . . . . . . . "Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications."@en . . . . . . . . . . . . "approved"@en . . . . . "Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome."@en . . "Parametadione"@en . . . . "Paradione"@en . . . "Rapid via the digestive tract."@en . "12 to 24 hours (however the half-life for the active metabolite is not known)"@en . . . "Paramethadionum"@en . . . "Symptoms of overdose include clumsiness or unsteadiness, coma, severe dizziness, severe drowsiness, severe nausea, and problems with vision."@en . "Dione anticonvulsants such as paramethadione reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons). This inhibits corticothalamic transmission and raises the threshold for repetitive activity in the thalamus. This results in a dampening of the abnormal thalamocortical rhythmicity proposed to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram (EEG) during absence seizures."@en . . "# Hoffman DJ, Chun AH: Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose. J Pharm Sci. 1975 Oct;64(10):1702-3. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/1185541 # Feldman GL, Weaver DD, Lovrien EW: The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome. Am J Dis Child. 1977 Dec;131(12):1389-92. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/412416"@en . . . . "Humans and other mammals"@en . . "Parametadiona"@en .