. "Rifabutinum"@en . "approved"@en . . . . "Rifabutina"@en . "A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]"@en . "LD₅₀ = 4.8 g/kg (mouse, male)"@en . "85%"@en . . "Rifabutin"@en . "Take with food to reduce irritation."@en . . . "* 0.69 +/- 0.32 L/hr/kg"@en . . . . "Mycobacterium leprae"@en . . . . . . . . . . . . . . . . . "72559-06-9"@en . . . . . " "@en . . "Mycobacterium avium"@en . . . . "Mycobutin (tn)"@en . . . "Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%."@en . . "For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection."@en . . . . "Ansamicin"@en . . "A mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces."@en . . "4-N-Isobutylspiropiperidylrifamycin S"@en . . "Rifabutine"@en . . "45 (± 17) hours"@en . . "4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S"@en . "Mycobacterium tuberculosis"@en . . "High-fat meals slow the rate of absorption."@en . . "1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv"@en . "Enteric bacteria and other eubacteria"@en . "Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death."@en . "Rifabutin"@en . . . . . . . . "Ansamycin"@en . .