"investigational"@en . . . "3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine"@en . . . . . . . . . . . "Take without regard to meals."@en . . . . "Lamotrigine"@en . . . . . "* 0.9 to 1.3 L/kg"@en . . . . . . . . "approved"@en . . . . . . "Humans and other mammals"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Lamotriginum"@en . . "Lamictal"@en . . . . . . . . . . . . . . . . . . . . . . . . . . "LD₅₀=250 (mg/kg) (in rat, mice); LD₅₀>640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs."@en . . . . "For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression. "@en . . . . . . . . . "Lamotrigina"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown. [Wikipedia]"@en . . . . . "25 +/- 10 hours (healthy individuals); 42.9 hours (chronic renal failure)"@en . . . "Grahame Roy Lee, \"Process for the preparation of lamotrigine.\" U.S. Patent US5925755, issued January, 1981."@en . . . . "84057-84-1"@en . . . "One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels and/or calcium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine show binding to sodium channels similar to local anesthetics. "@en . . . . . . . . . . . . . . . . . . . . "* Apparent plasma cl=0.44 mL/min/kg [healthy volunteers taking single-dose LAMICTAL] * Apparent plasma cl=0.58 mL/min/kg [healthy volunteers taking multiple-dose LAMICTAL] * Apparent plasma cl=0.30 mL/min/kg [healthy volunteers taking valproate and single-dose LAMICTAL] * Apparent plasma cl=0.18 mL/min/kg [healthy volunteers taking valproate and multiple-dose LAMICTAL] * Apparent plasma cl=1.1 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and single-dose LAMICTAL] * Apparent plasma cl=1.12 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and multiple-dose LAMICTAL]"@en . . . . . . . . . . . . . . . . . . "Lamotrigine"@en . "# Backonja M: Neuromodulating drugs for the symptomatic treatment of neuropathic pain. Curr Pain Headache Rep. 2004 Jun;8(3):212-6. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15115640 # Barbosa L, Berk M, Vorster M: A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry. 2003 Apr;64(4):403-7. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12716240 # Jensen TS: Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain. 2002;6 Suppl A:61-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11888243 # Pappagallo M: Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine. Clin Ther. 2003 Oct;25(10):2506-38. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/14667954 # Tehrani SP, Daryaafzoon M, Bakhtiarian A, Ejtemaeemehr S, Sahraei H: The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19579915"@en . "98%"@en . "55%"@en . " "@en . . . .