. "Co-vidarabine"@en . . . "In man, following a single dose of 4 mg/m2 of pentostatin infused over 5 minutes, approximately 90% of the dose was excreted in the urine as unchanged pentostatin and/or metabolites as measured by adenosine deaminase inhibitory activity."@en . "Shigella"@en . . . . . . . . . "For the treatment of hairy cell leukaemia refractory to alpha interferon."@en . . . . . . "53910-25-1"@en . "* 68 mL/min/m2"@en . . . "Pentostatin"@en . . "Pentostatinum"@en . . . . . . "Borrelia burgdorferi"@en . . . "Escherichia coli"@en . "# \"Link\":http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Pentostatin.htm"@en . "Leptospira interrogans"@en . "Pentostatin"@en . . . . . . "Nipent"@en . . . . . . . . . . . "Klebsiella"@en . . . "Pentostatina"@en . "Staphylococcus aureus"@en . "Nadji Sourena, \"Process for the production of pentostatin aglycone and pentostatin.\" U.S. Patent US20040181052, issued September 16, 2004."@en . "4%"@en . . . . . "Salmonella typhi"@en . "A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. [PubChem]"@en . . . "Not absorbed orally, crosses blood brain barrier."@en . "Mycobacterium tuberculosis"@en . . "investigational"@en . . "Pentostatine"@en . . "Serratia marcescens"@en . "Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase)."@en . . "Pseudomonas aeruginosa"@en . "approved"@en . "Proteus vulgaris"@en . . " "@en . "Vibrio cholerae"@en . "5.7 hours (with a range between 2.6 and 16 hrs)"@en . . "LD₅₀=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression."@en . "Humans and other mammals"@en . .