"5-Fluorouracil"@en . . . . . "The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N5\u201310-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of DNA and RNA synthesis and cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate (UTP), producing a fraudulent RNA and interfering with RNA processing and protein synthesis."@en . . . . . . . . . "51-21-8"@en . . . . . . . . "FU"@en . . . . "LD₅₀=230mg/kg (orally in mice)"@en . . " "@en . "10-20 minutes"@en . . "Fluouracil"@en . . "5-Fluracil"@en . . . . . . . . . . "Leroy B. Townsend, Robert A. Earl, Steven J. Manning, \"Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil.\" U.S. Patent US3960864, issued October, 1969."@en . . . . . . . . "5-Fluoropyrimidine-2,4-dione"@en . . . . . . . . . . "Seven percent to 20% of the parent drug is excreted unchanged in the urine in 6 hours; of this over 90% is excreted in the first hour. The remaining percentage of the administered dose is metabolized, primarily in the liver."@en . . . . . . . . . . . . . . "28-100%"@en . . . . . . . . . . "Fluorouracil"@en . . . "Vitamin B1 needs increased with long term use."@en . . . . . . . . . . . . . . . . . . . . . "Fluorouracilo"@en . . . "Fluoro Uracil"@en . "A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. [PubChem]"@en . . "Humans and other mammals"@en . . . "Fluorouracil"@en . "5-FU"@en . . "For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid."@en . "approved"@en . . . . . "8-12%"@en . . . . . . . . . . . . . . . "# Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12724731 # Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15032669"@en . "Fluorouracilum"@en . . . . . "5-Fluoracil"@en .