. "\"DrugSyn.org\":http://www.drugsyn.org/Buspirone.htm"@en . . . "36505-84-7"@en . . . . . . . . . "Oral, rat LD₅₀ = 136 mg/kg. Symptoms of overdose include dizziness, drowsiness, nausea or vomiting, severe stomach upset, and unusually small pupils."@en . . . . . . . . . . . "For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression."@en . . . . . "Rapidly absorbed in man. Bioavailability is low and variable (approximately 5%) due to extensive first pass metabolism."@en . "2-3 hours (although the action of a single dose is much longer than the short halflife indicates)."@en . . . . . . . . . . . . . . . . . . . "Buspiron"@en . . "8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione"@en . . . . . . "Take with food."@en . . "approved"@en . . . . "Buspirone"@en . . . . . . . "Avoid alcohol."@en . . "Buspironum"@en . . . "Always take at the same time with respect to meals."@en . . . . "Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of buspirone actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced."@en . . . . . . "95% (approximately 70% bound to albumin, 30% bound to alpha 1 -acid glycoprotein)"@en . . . . " "@en . . "Buspirona"@en . . . " "@en . . "In a single-dose study using 14C-labeled buspirone, 29% to 63% of the dose was excreted in the urine within 24 hours, primarily as metabolites; fecal excretion accounted for 18% to 38% of the dose."@en . . . . . . . . . . . . . . . . . . . "Avoid taking grapefruit or grapefruit juice throughout treatment."@en . . . . . . . . . . . . . . . . . . . . . "investigational"@en . . . . . . . . "An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. [PubChem]"@en . . "Humans and other mammals"@en . . . . . . . . . "Buspirone"@en . . . . . . . . .