. . . "Dipivefrin"@en . . . " "@en . . "Dipivefrina"@en . . . . . . . . . . . "Dipivefrinum"@en . . . . . . "Dipivefrin"@en . . . "Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating \u03B1 -and/or \u03B2₂-adrenergic receptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy."@en . "Dipivalyl Epinephrine "@en . "Dipiv\u00E9frine"@en . . "Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops)."@en . . . . "(+-)-4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate"@en . . . . . . . . "4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate"@en . " "@en . . . . . . . . "Pro-Epinephrine"@en . . . . "Oral LD₅₀ in rat is 183 mg/kg."@en . . . . . "approved"@en . . . "Well absorbed following occular administration."@en . . . . "Hussain, A. and Truelove, J.E.; U.S. Patents 3,809.714; May 7,1974; and 3,839,584; October 1, 1974; both assigned to Inter Rx Research Corp. Henschler, D., Wagner, J. and Hampel, H.; US. Patent 4,085,270; April 18,1978; assigned to Chemisch-Pharmazeutische Fabrik Adolf Klinge & Co. (W. Germany)."@en . . . "Humans and other mammals"@en . . "1-(3',4'-Dipivaloyloxyphenyl)-2-methylamino-1-ethanol"@en . "Dipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma."@en . . . "52365-63-6"@en .