. . "approved"@en . . . . . . . "96%"@en . "Goldberg, M.; U.S. Patent 3,265,573; August 9, 1966; assigned to E.R. Squibb & Sons, Inc. Lund, F., Lyngby, K. and Godtfredsen, W.O.; U.S. Patent 3,392,168; July 9, 1968; assigned to Lovens Kemiske Fabrik ved A. Kongsted, Denmark."@en . . . . . "Humans and other mammals"@en . . . . . . . . . . . . . . . "For the treatment of high blood pressure and management of edema related to heart failure."@en . . . . . . . " "@en . "Bendrofluazide"@en . "A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)"@en . . . "As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle."@en . . . . . . "73-48-3"@en . "Bendroflumetiazida"@en . . . "6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide"@en . . . . . "Bendroflumethiazidum"@en . . . . "Absorbed relatively rapidly after oral administration"@en . "Take with food to increase bioavailability."@en . . "Bendroflumethiazid"@en . "+--3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide"@en . . "Bendroflumethiazide"@en . . . . . . . "8.5 hours"@en . . . . . "Benzhydroflumethiazide"@en . . . . "Bendroflum\u00E9thiazide"@en .