. . . "gamma-HCH"@en . . "Lindan"@en . . . "\u03B3-hexachlorocyclohexane"@en . "91%"@en . "Benzene hexachloride"@en . "gamma-Benzene hexachloride"@en . . "18 hours"@en . "Gammallin"@en . . "Lindane is a moderately toxic compound via oral exposure, with a reported oral LD₅₀ of 88 to 190 mg/kg in rats. Gamma-HCH (which constitutes 99% of lindane) is generally considered to be the most acutely toxic of the isomers following single administration. It is moderately toxic via the dermal route as well, with reported dermal LD₅₀ values of 500 to 1000 mg/kg in rats, 300 mg/kg in mice, 400 mg/kg in guinea pigs, and 300 mg/kg in rabbits. Acute exposure to lindane may lead to central nervous system stimulation (usually developing within 1 hour), mental/motor impairment, excitation, clonic (intermittent) and tonic (continuous) convulsion. Other adverse reactions include central nervous system toxicity, as well as skin and gastrointestinal changes."@en . . . . . . "1,2,3,4,5,6-Hexachlorocyclohexane"@en . "gamma-1,2,3,4,5,6-Hexachlorocyclohexane"@en . . . . . "(1R,2c,3t,4c,5c,6t)-1,2,3,4,5,6-Hexachlorocyclohexane"@en . . . . . . . . . . . . . . . "For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies."@en . . . . . . "(1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-Hexachlorocyclohexane"@en . . . "approved"@en . . . . . . "gamma-Hexachlorzyklohexan"@en . "# Brown VJ: Life after lindane in California. Environ Health Perspect. 2008 Mar;116(3):A128. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/18335087 # Strong M, Johnstone PW: Interventions for treating scabies. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000320. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17636630"@en . "Lindane is an organochloride insecticide that has similar neurotoxic protperties to DDT. It exerts its parasiticidal action by being directly absorbed through the parasite's exoskeleton (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for lindane, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system. This results in paralysis, convulsions, and death. Lindane has very low ovicidal activity."@en . "\u03B3-lindane"@en . . . . "Kwell"@en . "Gammaxene"@en . . "Lindane"@en . "Scabies (Sarcoptes scabei) and other insects"@en . . . . . . . "withdrawn"@en . . "gamma-BHC"@en . . . "Lindane is absorbed significantly through the skin. A mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of lindane lotion for scabies."@en . . . . . "58-89-9"@en . "An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment. Lindane is still allowed for pharmaceutical use until 2015. "@en . . . . "gamma-Lindane"@en . . " "@en . "\u03B3-Hexachlorzyklohexan"@en . "gamma-Hexachlorocyclohexane"@en . . . .