. "12650-69-0"@en . . . . "Following the application of Centany (mupirocin ointment),2% to a 400 cm2 area on the back of 23 healthy volunteers once daily for 7 days, the mean (range) cumulative urinary excretion of monic acid over 24 hrs following the last administration was 1.25% (0.2% to 3.0%) of the administered dose of mupirocin."@en . . . "Pseudomonic acid"@en . . . . . "Mupirocin"@en . "Staphylococcus aureus"@en . . "Bactroban"@en . . . . . . . . . "No measurable systemic absorption"@en . "97%"@en . . . . . . . . . "Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance."@en . . . . . . . "For the treatment of Staphylococci nasal carriers."@en . . . . . "Centany"@en . . . . . . . . . . . "Enteric bacteria and other eubacteria"@en . "approved"@en . . . . . . . . . . . . . . . . . . "Harvey Lee Zimmerman, \"Pharmaceutical and veterinary compositions of mupirocin and methods for their preparation.\" U.S. Patent US6025389, issued January, 1988."@en . . . . . . . "Mupirocine"@en . . "20 to 40 minutes"@en . . "Pseudomonic acid a"@en . . . " "@en . . . . " "@en . "Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Prevention of this enzymes from functioning properly results in the inhibition of bacterial protein and RNA synthesis."@en . "Mupirocinum"@en . . . . . . . "9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid"@en . . . "Mupirocina"@en . . . . . . . "investigational"@en . .