. "2 to 4 hours"@en . . . "# Qizilbash N, Whitehead A, Higgins J, Wilcock G, Schneider L, Farlow M: Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration. JAMA. 1998 Nov 25;280(20):1777-82. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/9842955 # Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/20480924"@en . "withdrawn"@en . . . "Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17%."@en . . . "The mechanism of tacrine is not fully known, but it is suggested that the drug is an anticholinesterase agent which reversibly binds with and inactivates cholinesterases. This inhibits the hydrolysis of acetylcholine released from functioning cholinergic neurons, thus leading to an accumulation of acetylcholine at cholinergic synapses. The result is a prolonged effect of acetylcholine."@en . . . . . . . . "S. Shirley Yang, Wayne Boisvert, Nouman A. Muhammad, Jay Weiss, \"Controlled release tacrine drug delivery systems and methods for preparing same.\" U.S. Patent US5576022, issued February, 1993."@en . . . "THA"@en . . "Tetrahydroaminacrine"@en . . . . . "1,2,3,4-tetrahydroacridin-9-amine"@en . . "Tacrine"@en . . . . "Tacrinum"@en . . . . "For the palliative treatment of mild to moderate dementia of the Alzheimer's type."@en . . . . "Tetrahydroaminoacridine"@en . . "Humans and other mammals"@en . "Overdosage with cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. The estimated median lethal dose of tacrine following a single oral dose in rats is 40 mg/kg, or approximately 12 times the maximum recommended human dose of 160 mg/day."@en . . "* 349 \u00B1 193 L"@en . . " "@en . "Tacrine"@en . . . . . . . "321-64-2"@en . . . . . . . . . . "55%"@en . . . . "Tacrin"@en . "A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. "@en . " "@en .