. "Oral, mouse: LD₅₀ = 440 mg/kg; Oral, rat: LD₅₀ = 763 mg/kg; Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting."@en . . . "Take without regard to meals."@en . . . . . . . . "5-chloro-2-Benzoxazolinone"@en . . . . . . . . . . . "Chlorzoxazone"@en . . . . . . "Chlorzoxazone"@en . . . . . "2-hydroxy-5-chlorobenzoxazole"@en . . . . . "Avoid alcohol."@en . . . . . . . . . . "5-chloro-2-Hydroxybenzoxazole"@en . "# Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF: Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6. Epub 2006 Jun 29. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16859676 # Park JY, Kim KA, Park PW, Ha JM: Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe. J Clin Pharmacol. 2006 Jan;46(1):109-14. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16397290 # Wan J, Ernstgard L, Song BJ, Shoaf SE: Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats. J Pharm Pharmacol. 2006 Jan;58(1):51-61. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16393464"@en . . . . . . . "Humans and other mammals"@en . . . . . "Chlorzoxane"@en . . . "Clorzoxazona"@en . "5-chloro-2-Benzoxazolone"@en . "Chlorzoxazonum"@en . . . . . "Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium and potassium influx which would lead to neuronal inhibition and muscle relaxation. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm"@en . . . . . . "Chlorzoxazona"@en . . "approved"@en . "13-18%"@en . "5-chlorobenzoxazolin-2-one"@en . . . "For the relief of discomfort associated with acute painful musculoskeletal conditions."@en . . . . "Clorzoxazone"@en . . "5-chloro-3H-benzooxazol-2-one"@en . . "A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)"@en . "Chlorzoxazon"@en . " "@en . . . . "Marsh, D.F.; US. Patent 2,895,877; July 21, 1959; assigned to McNeil Laboratories, Inc."@en . . . . . . . . . . . . . "5-chloro-2(3H)-benzoxazolone"@en . . . . . . . . . . . . . . "Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide."@en . . . "5-Chlorobenzoxazolidone"@en . . "95-25-0"@en . . . . . . . . . "5-chloro-2-Benzoxazolol"@en . . . .