. . . "Bleomycinum"@en . . . . . . . . . . . . . . . . . "Bleocin"@en . . . . "For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas."@en . . . . . . . "115 minutes"@en . . . . . . . . . . . . . "11056-06-7"@en . . "Bleomycin A2"@en . "Bleomicina"@en . "Hamao Umezawa, Kenji Maeda, Tomohisa Takita, Yuya Nakayama, Akio Fujii, Nobuyoshi Shimada, Hideo Chimura, \"Novel process for producing antibiotics bleomycin.\" U.S. Patent USRE0304514, issued October, 1970."@en . . . . . . "Bleomicin"@en . . "It was reported that patients with moderately severe renal failure excreted less than 20% of the dose in the urine."@en . "BLM"@en . . . " "@en . "A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin."@en . . "Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA."@en . . "Bleomycin"@en . "# Claussen CA, Long EC: Nucleic Acid recognition by metal complexes of bleomycin. Chem Rev. 1999 Sep 8;99(9):2797-816. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11749501"@en . "Bleomycine"@en . " "@en . . . "approved"@en . "Systemic absorption is approximately 45%."@en . . . . . . . . "Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction."@en . . . . . . . . "1%"@en . "Humans and other mammals"@en . . .