. . . . . "* 5.1 L/kg/hr [infusion doses up to 40\u00A0mcg/kg/min]"@en . . . . . . . . "74863-84-6"@en . . . . . . "Argatroban"@en . . . . . . . . . "Herbs and food with anticoagulant/antiplatelet activity. Major interactions may occur with danshen, dong quai, evening primrose oil, gingko, policosanol, willow bark"@en . . . . "Excessive bleeding"@en . "Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban."@en . "Tomiya Mano, Jin Shiomura, \"Argatroban preparations for ophthalmic use.\" U.S. Patent US5506241, issued October, 1986."@en . . . "39 and 51 minutes"@en . . . "Humans and other mammals"@en . . "investigational"@en . . "Argatroban is indicated for prevention and treatment of thrombosis caused by heparin induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention."@en . . "* 174 mL/kg * 12.18 L [70-kg adult]"@en . "approved"@en . . . . . . . . . . "Bioavailability is 100% (intravenous)."@en . "54%"@en . . "# Di Nisio M, Middeldorp S, Buller HR: Direct thrombin inhibitors. N Engl J Med. 2005 Sep 8;353(10):1028-40. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16148288"@en . . . . . . "Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation."@en . . . "Argatroban is excreted primarily in the feces (65%), presumably through biliary secretion; 22% is eliminated via urine."@en . .