" "@en . "6.9 hours (range 4.0-11.3)"@en . . . . . . . . "Fungi"@en . . . . . "The oral LD₅₀ values were found to be 1741 and 849 mg/kg for the male and female in rat."@en . "94.9%"@en . . . . . "Terconazole"@en . . . . . . . . . . . . . . . . . . . . . "Following oral (30 mg) administration of 14C-labelled terconazole, excretion of radioactivity was both by renal (32-56%) and fecal (47-52%) routes."@en . . . "For the treatment of candidiasis (a yeast-like fungal infection) of the vulva and vagina."@en . "Terconazole may exert its antifungal activity by disrupting normal fungal cell membrane permeability. Terconazole and other triazole antifungal agents inhibit cytochrome P450 14-alpha-demethylase in susceptible fungi, which leads to the accumulation of lanosterol and other methylated sterols and a decrease in ergosterol concentration. Depletion of ergosterol in the membrane disrupts the structure and function of the fungal cell leading to a decrease or inhibition of fungal growth."@en . . . . . "Following intravaginal administration of terconazole in humans, absorption ranged from 5-8% in three hysterectomized subjects and 12-16% in two non-hysterectomized subjects with tubal ligations"@en . . . . "approved"@en . . . . . . . . . . . . . . . "Terconazole is an anti-fungal medication, primarily used to treat vaginal fungal infections. [Wikipedia]"@en . . . . . . . . . . . . . . . . . . . . . . . . . "Terazol 3"@en . "67915-31-5"@en .