"Nevirapine"@en . "Nevirapine"@en . . . . . "Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease. The most common adverse reaction is rash. "@en . . . "Take without regard to meals."@en . . . . . . . . . . . "Avoid alcohol."@en . . . . . . . "NEV"@en . . . . "11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one"@en . . . "Nevirapine is readily absorbed (greater than 90%) after oral administration in healthy subjects and adults with HIV-1 infection. The absolute bioavailability in healthy adults following a single dose administration is 93 \u00B1 9% (mean \u00B1 SD) for a 50 mg tablet and 91 \u00B1 8% for an oral solution. Peak plasma nevirapine concentrations of 2 \u00B1 0.4 mcg/mL (7.5 micromolar) were attained by 4 hours following a single 200 mg dose. Nevirapine tablets and suspension have been shown to be comparably bioavailable and interchangeable at doses up to 200 mg. When the oral tablet is given with a high-fat meal, the extent of absorption is compared to that of the fasted-state. "@en . . . "NVP"@en . "60% bound to plasma protein. "@en . "Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates."@en . . . "Thus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (<5%) of the radioactivity in urine (representing <3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound."@en . " "@en . . . . "A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. [PubChem] Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. "@en . . . "129618-40-2"@en . . . . . . "Viramune"@en . "approved"@en . . . . . "For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection."@en . . "* 1.21 \u00B1 0.09 L/kg [apparent volume of distribution, healthy adults, IV] Nevirapine is capable of crossing the placenta and is found in breast milk. "@en . . . . . . . . . "Human Immunodeficiency Virus"@en . . . . . . "45 hours"@en . "# FDA label "@en . . . . . . . . "\"DrugSyn.org\":http://www.drugsyn.org/Nevirapine.htm"@en . .