"* 21.8 \u00B1 13.9 L [Volunteers] * 19.8 \u00B1 12.7 L [Patients with Type 2 diabetes, Single Dose] * 37.1 \u00B1 18.2 L [Patients with Type 2 diabetes, Multiple Dose]"@en . . "Glim\u00E9piride"@en . . "Even though food reduces product absorption, the manufacturer recommends taking the product with the first meal of the day."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "approved"@en . . . . . . . "Glimepiridum"@en . "Glimepiride"@en . . "Avoid alcohol."@en . . . . "Glimepiride is the first III generation sulphonyl urea it is a very potent sulphonyl urea with long duration of action."@en . . . . . . "93479-97-1"@en . . . "Amaryl"@en . . "Humans and other mammals"@en . . . . . . "Severe hypoglycemic reactions with coma, seizure, or other neurological impairment."@en . . . . . . . . . . . . . " "@en . . . . . . "Over 99.5% bound to plasma protein."@en . . . . . "Approximately 5 hours following single dose."@en . "Completely (100%) absorbed following oral administration."@en . . . . . . "Suresh Kadam, Venkatasubramanian Tarur, Sanjay Naik, Sachin Gavhane, \"Process for preparation of substantially pure glimepiride.\" U.S. Patent US20070082943, issued April 12, 2007."@en . . . . . . . . "* 52.1 +/- 16.0 mL/min [Normal subjects with single oral dose] * 48.5 +/- 29.3 mL/min [Patients with Type 2 diabetes, with single oral dose] * 52.7 +/- 40.3 mL/min [Patients with Type 2 diabetes, with multiple oral dose] * 47.8 mL/min [healthy after intravenous (IV) dosing]"@en . . . . . . . . . . . . . . . . "Glimepirida"@en . . . . "The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin."@en . "For concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus."@en .