. . . . . . . . "Trospium"@en . "After administration of oral 14C-trospium chloride, the majority of the dose (85.2%) was recovered in feces and a smaller amount (5.8% of the dose) was recovered in urine; 60% of the radioactivity excreted in urine was unchanged trospium. The mean renal clearance for trospium (29.07 L/hour) is 4-fold higher than average glomerular filtration rate, indicating that active tubular secretion is a major route of elimination for trospium. SANCTURA \u00AE is metabolized by ester hydrolysis and excreted by the kidneys by a combination of tubular secretion and glomerular filtration."@en . . . . . . . . "approved"@en . . "10405-02-4"@en . "50-85%"@en . "For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition."@en . " "@en . . . . "* 395 \u00B1 140 L"@en . . . . "9.6%"@en . . . . . "Humans and other mammals"@en . . . . . . . . . "20 hours"@en . . . . . . . . . . . . . . . "Trospium antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder."@en . . "* Renal cl=29.07 L/hour"@en . . . . . . . . . "Trospium is a urinary antispasmodic. It is sold under the brand name Sanctura in the US, and as Trosec in Canada. [Wikipedia]"@en . . .