. . "Chloridine"@en . . . . . . "Primethamine"@en . . . . . "2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidine"@en . . "58-14-0"@en . . "5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine"@en . "Ethylpyrimidine"@en . "Diaminopyritamin"@en . . . . . . "One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [PubChem]"@en . "2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine"@en . . . . . . . . . . . . . "Well absorbed with peak levels occurring between 2 to 6 hours following administration"@en . "CD"@en . . . "87%"@en . . . . "Pyrimethaminum"@en . " "@en . . "approved"@en . "2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine"@en . "\"DrugSyn.org\":http://www.drugsyn.org/Pyrimethamine.htm"@en . . . "Plasmodium"@en . . . " "@en . . . . . . . . . . "5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine"@en . "Pirimetamina"@en . "96 hours"@en . . . . "Folic acid needs increased."@en . "For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine"@en . . . . "5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine"@en . . . "Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver."@en . . . "# Gatton ML, Martin LB, Cheng Q: Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum. Antimicrob Agents Chemother. 2004 Jun;48(6):2116-23. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15155209 # Sirichaiwat C, Intaraudom C, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y: Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem. 2004 Jan 15;47(2):345-54. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/14711307"@en . "Take with food to reduce irritation."@en . . "Chloridyn"@en . . "Pyrimethamine"@en . .