" "@en . "* 25 L/kg"@en . . "Fluvoxaminum"@en . . "Humans and other mammals"@en . . . . . . . . . . "# Dell'Osso B, Allen A, Hollander E: Fluvoxamine: a selective serotonin re-uptake inhibitor for the treatment of obsessive-compulsive disorder. Expert Opin Pharmacother. 2005 Dec;6(15):2727-40. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16316311 # Irons J: Fluvoxamine in the treatment of anxiety disorders. Neuropsychiatr Dis Treat. 2005 Dec;1(4):289-99. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/18568110"@en . . . . . . . . . . . . . . . . "Welle, H.B.A. and Claassen, V.; U.S. Patent 4,085,225; April 18, 1978; assigned to U.S. Phillips Corp."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " "@en . . . . . . . . . . . "Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly increase serum levels of this product."@en . . . . . . . . . . . . "15.6 hours"@en . . . . . . . . . "For management of depression and for Obsessive Compulsive Disorder (OCD). Has also been used in the management of bulimia nervosa."@en . . . . . . . . . . "Take without regard to meals."@en . "Well absorbed, bioavailability of fluvoxamine maleate is 53%."@en . . "investigational"@en . . . . . "Side effects include anorexia, constipation, dry mouth, headache, nausea, nervousness, skin rash, sleep problems, somnolence, liver toxicity, mania, increase urination, seizures, sweating increase, tremors, or Tourette's syndrome."@en . . "Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients. It was launched in the US in December 1994 and in Japan in June 1999. As of the end of 1995, more than 10 million patients worldwide have been treated with fluvoxamine."@en . "Fluvoxamine"@en . . . . . . . . "The main human metabolite was fluvoxamine acid which, together with its N-acetylated analog, accounted for about 60% of the urinary excretion products. Approximately 2% of fluvoxamine was excreted in urine unchanged. Following a 14C-labelled oral dose of fluvoxamine maleate (5 mg), an average of 94% of drug-related products was recovered in the urine within 71 hours."@en . . "Fluvoxamina"@en . "54739-18-3"@en . . . "Avoid alcohol."@en . . "The exact mechanism of action of fluvoxamine has not been fully determined, but appears to be linked to its inhibition of CNS neuronal uptake of serotonin. Fluvoxamine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. In-vitro studies suggest that fluvoxamine is more potent than clomipramine, fluoxetine, and desipramine as a serotonin-reuptake inhibitor. Studies have also demonstrated that fluvoxamine has virtually no affinity for \u03B1₁- or \u03B1₂-adrenergic, \u03B2-adrenergic, muscarinic, dopamine D₂, histamine H₁, GABA-benzodiazepine, opiate, 5-HT₁, or 5-HT₂ receptors."@en . . "Avoid high doses of caffeine."@en . . . . . "approved"@en . . . . . "Fluvoxamine"@en . "~77-80% (plasma protein)"@en .