"Diagnosis and treatment of inherited disorders II"@en . . "314"^^ . . "2011-03-01+01:00"^^ . "0"^^ . . "314"^^ . . . . . "0"^^ . . "2012-06-28+02:00"^^ . "Excellent results of the research plan (with international significance). The results of scientific work were successfuly transfered into clinical practice in the form of new diagnostic and therapeutic procedures, which allow to improve a diagnostics of hereditary conditioned diseases and to provide an adequate prevention for these diseases and their complications."@en . "2005-01-01+01:00"^^ . . . "1"^^ . "Vynikaj\u00EDc\u00ED v\u00FDsledky v\u00FDzkumn\u00E9ho z\u00E1m\u011Bru (s mezin\u00E1rodn\u00EDm v\u00FDznamem). Z\u00E1rove\u0148 se poda\u0159ilo v\u00FDsledky v\u011Bdeck\u00E9 pr\u00E1ce p\u0159en\u00E9st do klinick\u00E9 praxe v\u00A0podob\u011B nov\u00FDch diagnostick\u00FDch a\u00A0terapeutick\u00FDch postup\u016F, co\u017E umo\u017Enilo zlep\u0161it diagnostiku d\u011Bdi\u010Dn\u011B podm\u00EDn\u011Bn\u00FDch chorob a\u00A0stanovit pro tyto nemoci a jejich komplikace vhodnou prevenci."@cs . . "2011-12-31+01:00"^^ . . . "Vy\u0161et\u0159en\u00ED dal\u0161\u00EDch d\u011Bdi\u010Dn\u00FDch poruch metabolismu a hemost\u00E1zy, spojen\u00FDch s trombofili\u00ED a nov\u011B je zam\u011B\u0159en i na detekci polymorfism\u016F, kter\u00E9 prim\u00E1rn\u011B nebo sekund\u00E1rn\u011B souvis\u00ED se vznikem a progres\u00ED endokrinn\u00EDch n\u00E1dor\u016F, n\u00E1dor\u016F prsu, mozku a kolorekt\u00E1ln\u00EDho karcinnomu. Genetick\u00E9 vy\u0161et\u0159en\u00ED DNA je zde pl\u00E1nov\u00E1no doplnit o navazuj\u00EDc\u00ED oblast tzv. proteomiky. V laborato\u0159\u00EDch dojde t\u00E9\u017E k zaveden\u00ED mikrometod a k automatizaci izolace DNA, kter\u00E9 zv\u00FD\u0161\u00ED pot\u0159ebnou vy\u0161et\u0159ovac\u00ED kapacitu. V\u00FDsledky molekul\u00E1rn\u011B biologick\u00FDch test\u016F pak budou porovn\u00E1v\u00E1ny s n\u00E1lezy klinick\u00FDch a dal\u0161\u00EDch laboratorn\u00EDch a zobrazovac\u00EDch vy\u0161et\u0159en\u00ED, kter\u00E1 objektivizuj\u00ED zdravotn\u00ED stav vy\u0161et\u0159ovan\u00FDch jedinc\u016F. Zlep\u0161en\u00ED diagnostiky d\u011Bdi\u010Dn\u011B podm\u00EDn\u011Bn\u00FDch poruch, stanoven\u00ED vhodn\u00E9 prim\u00E1rn\u00ED a sekund\u00E1rn\u00ED prevence sledovan\u00FDch chorob a jejich komplikac\u00ED v klinick\u00E9 praxi." . "metabolic and haemostasis disorders; thrombophilia; colorectal carcinoma; cardiovascular diseases; DNA"@en . "Diagnostika a l\u00E9\u010Dba geneticky podm\u00EDn\u011Bn\u00FDch poruch II" . . "Further hereditary metabolic and haemostasis disorders examination connected with thrombophilia and it is now also concentrated on polymorphism detection, that are primary or secondary related to genesis and progression of endocrinous, breast and brain tumours, colorectal carcinoma and cardiovascular diseases. Genetic examinations of DNA are planned to complete with related field of proteomics. New micro-methods and automation of DNA isolation will be set up in laboratories, which increase necessary assays capacity. The results of molecular-biological tests will be compared with clinical and further laboratory and depictive findings, which objectify health condition of examined individuals. Improvement of hereditary determined diseases diagnostics, selection of primary and secondary prevention of observed diseases and their investigated complications in a medical practice."@en . . . .