"348"^^ . "2011-01-26+01:00"^^ . "Diseases of the vascular system represent important problem at present time because they contribute to morbidity and mortality in the population worldwide. Increment of vascular diseases contributing to about one half of death has been repeatedlydemonstrated in the last years. It may be caused by cumulation of the risk factors either endogeneous (genetically determined) or exogeneous originating from the environment. Their combination amplificate negative influence on the vascular syst\u00E9mmanifesting in every part of the vasculature but mainly in parts where organs are strongly dependent on the normal physiological function of the blood (i.e. exchange of gases, nutrients etc.)."@en . . . . . . "P\u0159edm\u011Btem VZ je v klinick\u00E9 \u010D\u00E1sti definov\u00E1n\u00ED, diagnostika a terapeutick\u00E9 ovlivn\u011Bn\u00ED hroz\u00EDc\u00EDch rizik c\u00E9vn\u00EDch posti\u017Een\u00ED (v oblasti kardiovaskul\u00E1rn\u00ED, cerebrovaskul\u00E1rn\u00ED a renovaskul\u00E1rn\u00ED) u populace s endogenn\u011B i exogenn\u011B podm\u00EDn\u011Bn\u00FDm zv\u00FD\u0161en\u00FDm sklonem k t\u011Bmto komjednak anal\u00FDza genetick\u00FDch, metabolick\u00FDch, endokrinn\u00EDch a humor\u00E1ln\u00EDch p\u0159\u00ED\u010Din vedouc\u00EDch k posti\u017Een\u00ED c\u00E9vn\u00ED st\u011Bny u vytypovan\u00FDch rizikov\u00FDch jedinc\u016F a jednak testov\u00E1n\u00ED nov\u00FDch terapeutick\u00FDch postup\u016F. VZ \u0159e\u0161\u00ED problematiku onemocn\u011Bn\u00ED, kter\u00E1 vedou k c\u00E9vn\u00EDm komplmorbiditu a mortalitu posti\u017Een\u00E9 populace, jej\u00ED\u017E v\u00FDskyt trvale nar\u016Fst\u00E1. P\u0159edkl\u00E1dan\u00FD VZ tak bezprost\u0159edn\u011B nav\u00E1\u017Ee na VZ \u0159e\u0161en\u00FD v letech 1999-2004, jeho\u017E je p\u0159\u00EDm\u00FDm pokra\u010Dov\u00E1n\u00EDm. V\u00FDznam dlouhodob\u00E9ho projektu spo\u010D\u00EDv\u00E1 ve vytvo\u0159en\u00ED zd\u016Fvodn\u011Bn\u00FDch diagnostick\u00FDch ana prevenci c\u00E9vn\u00EDch zm\u011Bn u studovan\u00FDch chorob. V\u00FDstupem by m\u011Bla b\u00FDt opat\u0159en\u00ED vedouc\u00ED t\u00E9\u017E k prim\u00E1rn\u00ED prevenci posti\u017Een\u00ED c\u00E9v.V \u010D\u00E1sti v\u011Bnovan\u00E9 z\u00E1kladn\u00EDmu v\u00FDzkumu budou analyzov\u00E1ny faktory ovliv\u0148uj\u00EDc\u00ED rozvoj c\u00E9vn\u00EDch zm\u011Bn z hlediska patogenetick\u00FDch mechanism\u016F" . "348"^^ . . "The vascular complications of metabolic and endocrine diseases including the influence of a number of external factors were studied. Interdisciplinary approach made it possible to reach a number of original results in both basic research and clinical practice. New diagnostic biomarkers were developed and several treatments were evaluated. The authors described effect of oxidative stress on devel"@en . . "Metabolick\u00E9, endokrinn\u00ED a genetick\u00E9 aspekty prevence, diagnostiky a terapie kardiovaskul\u00E1rn\u00EDch, cerebrovaskul\u00E1rn\u00EDch a renovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED" . . . "cardiovascular diseases; cerebrovascular diseases; renovascular diseases"@en . "0"^^ . . "2005-01-01+01:00"^^ . . . "2012-08-17+02:00"^^ . "0"^^ . . . "1"^^ . . . "VZ se zab\u00FDval studiem p\u0159\u00ED\u010Din vzniku c\u00E9vn\u00EDch zm\u011Bn u \u0159ady metabolick\u00FDch a endokrinn\u00EDch chorob v\u010Detn\u011B vlivu toxick\u00FDch faktor\u016F zevn\u00EDho prost\u0159ed\u00ED. Interdisciplin\u00E1rn\u00ED v\u00FDzkum umo\u017Enil badatel\u016Fm dos\u00E1hnout \u0159ady origin\u00E1ln\u00EDch v\u00FDsledk\u016F jak v z\u00E1kladn\u00EDm v\u00FDzkumu, tak v klinick\u00E9 praxi. Byly stanoveny nov\u00E9 diagnostick\u00E9 biomarkery a ov\u011B\u0159eny r\u016Fzn\u00E9 l\u00E9\u010Debn\u00E9 postupy. Autor\u016Fm se poda\u0159ilo popsat vliv oxida\u010Dn\u00EDho stresu na"@cs . "Metabolic, endocrine and genetic aspects of the prevention, diagnosis and therapy of cardiovascular, cerebrovascular and renovascular diseases"@en . . . . "2011-12-31+01:00"^^ .