. "0"^^ . "Preparation, evaluation, pre-clinical testing and drug formulation of new biologically active substances - potential drugs, affecting reactive forms of oxygen."@en . . "Synt\u00E9za origin\u00E1ln\u00EDch l\u00E1tek s antioxida\u010Dn\u00EDm, antiulcerozn\u00EDm a kognitivn\u011B zesiluj\u00EDc\u00EDm \u00FA\u010Dinkem, jejich fyzik\u00E1ln\u011B chemick\u00E9 vlastnosti. P\u0159\u00EDprava peror\u00E1ln\u00EDch l\u00E9kov\u00FDch forem s \u0159\u00EDzenou liberac\u00ED. Anal\u00FDzy spot\u0159eby l\u00E9\u010Div."@en . "P\u0159\u00EDprava, hodnocen\u00ED, preklinick\u00E9 studium a l\u00E9kov\u00E1 formulace nov\u00FDch biologicky aktivn\u00EDch l\u00E1tek - potenci\u00E1ln\u00EDch l\u00E9\u010Div, ovliv\u0148uj\u00EDc\u00EDch aktivn\u00ED formy kysl\u00EDku." . "0"^^ . "Free oxygen radicals, antioxidant preparation, preclinical testing, drug formulation, directed liberation"@en . "Synt\u00E9za origin\u00E1ln\u00EDch l\u00E1tek s antioxida\u010Dn\u00EDm, antiulcerozn\u00EDm a kognitivn\u011B zesiluj\u00EDc\u00EDm \u00FA\u010Dinkem, jejich fyzik\u00E1ln\u011B chemick\u00E9 vlastnosti. P\u0159\u00EDprava peror\u00E1ln\u00EDch l\u00E9kov\u00FDch forem s \u0159\u00EDzenou liberac\u00ED. Anal\u00FDzy spot\u0159eby l\u00E9\u010Div."@cs . . "1"^^ . "12"^^ . . "Preparation, evaluation, pre-clinical testing and drug formulation of new biologically active substances, capable of trapping free oxygen radicals (acting as oxygen radical scavengers).The preparation involves the synthesis of original structures, i.e. isolation of secondary metabolites from higher plants. Preparation of derivatives from substances exhibiting biological effect and determination of the relations between the chemicalstructure and biological activity. Pre-clinical in-vitro and in-vivo assays in selected substances capable of exerting influence on reactive forms of oxygen. Development of a drug system with controlled drug release and evaluation of its qualityparameters."@en . . "2"^^ . "463"^^ . "2008-06-02+02:00"^^ . . . . . . "463"^^ . . . . "P\u0159\u00EDprava, hodnocen\u00ED, preklinick\u00E9 testov\u00E1n\u00ED a l\u00E9kov\u00E1 formulace biologicky aktivn\u00EDch l\u00E1tek, schopn\u00FDch vychyt\u00E1vat (zh\u00E1\u0161et) voln\u00E9 kysl\u00EDkov\u00E9 radik\u00E1ly. P\u0159\u00EDprava zahrnuje synt\u00E9zu p\u016Fvodn\u00EDch struktur, resp. izolaci sekund\u00E1rn\u00EDch metabolit\u016F z vy\u0161\u0161\u00EDch rostlin.P\u0159\u00EDprava deriv\u00E1t\u016F z l\u00E1tek vykazuj\u00EDc\u00EDch biologick\u00FD \u00FA\u010Dinek a hled\u00E1n\u00ED vztahu mezi chemickou strukturou a biologickou aktivitou. U vybran\u00FDch l\u00E1tek, schopn\u00FDch ovlivnit reaktivn\u00ED formy kysl\u00EDku, preklinick\u00E9 testov\u00E1n\u00ED v podm\u00EDnk\u00E1ch in vitro a in vivo.V\u00FDvoj l\u00E9kov\u00E9ho syst\u00E9mu se sm\u011B\u0159ovanou liberac\u00ED l\u00E9\u010Diva a hodnocen\u00ED jeho jakostn\u00EDch parametr\u016F." . . . . . .