"1"^^ . . "Research in biomedicine, particularly in cell biology and pathology, genotoxicology, teratology and neuroscience. Development and verification of analytical, diagnostic and therapeutic methods, based on the results of basic research in these fields. The research will be oriented to the molecular and cellular basis of human diseases, mainly those which arise as a result of the effects of negative environmental factors and the aquisition and differentiation of stem cells. The study will be concentrated on the pathological changes produced by unfavourable physical and chemical factors in the cell genome, cells and tissues during embryonal development and aging, autoimmune and demyelinating diseases and brain ischemia. The results will contribute to an understanding of the mechanisms of information processing within a cell, in the neuronal circuits of the CNS and in the extracellular space of the brain and to an understanding of their changes in human diseases."@en . . . . . . . . . . . "448"^^ . "0"^^ . "Dosa\u017Een\u00E9 v\u00FDsledky v oblasti neurov\u011Bd, bun\u011B\u010Dn\u00E9 biologie, genotoxikologie, kmenov\u00FDch bun\u011Bk, teratologie a farmakologie p\u0159isp\u011Bly k objasn\u011Bn\u00ED mechanism\u016F \u0159ady hum\u00E1nn\u00EDch onemocn\u011Bn\u00ED a budou vyu\u017Eity v klinick\u00E9 praxi p\u0159i v\u00FDvoji nov\u00FDch terapeutick\u00FDch postup\u016F."@cs . . . "0"^^ . "Results in the fields of neuroscience, cell biology, genotoxicology, stem cells, teratology and pharmacology helped to elucidate the mechanisms of human diseases and will be used in clinical practice for the development of new therapeutic approaches."@en . . "The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy"@en . "biomedicine;cell biology;genotoxicology;teratology;neuroscience;diagnosis;therapy;disease;environmental;pathological changes;embryonal development;aging;brain;genome;autoimmune and demyelimization diseases;physical and chemical factors"@en . . . "1"^^ . "448"^^ . . "2005-06-17+02:00"^^ . "1"^^ . . "Molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 z\u00E1klady vybran\u00FDch onemocn\u011Bn\u00ED lidsk\u00E9ho organismu, mechanismy norm\u00E1ln\u00ED a patologick\u00E9 funkce, principy diagnostiky a l\u00E9\u010Dby" . . . "V\u00FDzkum v biomedic\u00EDn\u011B zejm\u00E9na v bun\u011B\u010Dn\u00E9 biologii a patologii, genotoxikologii a teratologii, neurofyziologii, neuroanatomii a neurochemii. V\u00FDvoj a ov\u011B\u0159ov\u00E1n\u00ED analytick\u00FDch, diagnostick\u00FDch a terapeutick\u00FDch metod, zalo\u017Een\u00FDch na v\u00FDsledc\u00EDch z\u00E1kladn\u00EDho v\u00FDzkumu v t\u011Bchto oborech. V\u00FDzkum bude zam\u011B\u0159en na molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 z\u00E1klady hum\u00E1nn\u00EDch onemocn\u011Bn\u00ED, p\u0159edev\u0161\u00EDm t\u011Bch, kter\u00E1 vznikaj\u00ED negativn\u00EDm p\u016Fsoben\u00EDm civiliza\u010Dn\u00EDch faktor\u016F a na z\u00EDsk\u00E1n\u00ED a kontrolu diferenciace kmenov\u00FDch bun\u011Bk. Budou studov\u00E1ny patologick\u00E9 zm\u011Bny v genomu bu\u0148ky, v bu\u0148k\u00E1ch a tk\u00E1n\u00EDch v pr\u016Fb\u011Bhu embryon\u00E1ln\u00EDho v\u00FDvoje, st\u00E1rnut\u00ED, zm\u011Bny vyvolan\u00E9 p\u016Fsoben\u00EDm nep\u0159\u00EDzniv\u00FDch fyzik\u00E1ln\u00EDch a chemick\u00FDch faktor\u016F a zm\u011Bny v pr\u016Fb\u011Bhu autoimunitn\u00EDch a demyeliniza\u010Dn\u00EDch onemocn\u011Bn\u00ED a ischemie mozku. V\u00FDsledkem v\u00FDzkumu bude objasn\u011Bn\u00ED mechanism\u016F p\u0159enosu a zpracov\u00E1n\u00ED informace uvnit\u0159 bu\u0148ky, v nervov\u00FDch okruz\u00EDch CNS a extracelul\u00E1rn\u00EDm prostoru mozku a m\u00EDchy a objasn\u011Bn\u00ED zm\u011Bn, kter\u00E9 vznikaj\u00ED v pr\u016Fb\u011Bhu patologick\u00FDch proces\u016F." .