. "1"^^ . "Revealing the mechanism underlying the effect of therapeutic drugs modulating the activity of the immune and nervous systems in order to find new types of substances for clinical practice"@en . . . . . "0"^^ . . "Objasn\u011Bn\u00ED mechanismu \u00FA\u010Dinku farmak moduluj\u00EDc\u00EDch \u010Dinnost imunitn\u00EDho a nervov\u00E9ho syst\u00E9mu s c\u00EDlem nal\u00E9zt nov\u00E9 typy l\u00E1tek pro klinickou praxi" . . . . "Virostatika z acyklick\u00FDch nukleosidfosfon\u00E1t\u016F maj\u00ED imunostimula\u010Dn\u00ED vlastnosti. Nov\u00E9 alosterick\u00E9 modul\u00E1tory se v\u00E1\u017E\u00ED do ka\u017Ed\u00E9 podjednotky metabotropn\u00EDch glutam\u00E1tov\u00FDch receptor\u016F. Inhibitory aktivovan\u00FDch serinov\u00FDch a membr\u00E1nov\u00FDch prote\u00E1z zlep\u0161uj\u00ED hojen\u00ED."@cs . "1"^^ . . "25"^^ . "1"^^ . "2005-06-17+02:00"^^ . . . . "Immunomodulatory activity of acyclic nucleoside phosphonates was revealed. New allosteric modulators bind in each subunit of metabotropic glutamate receptor. Inhibitors of activated serine and membrane proteases enable healing processes."@en . "25"^^ . "immunomodulators;immune system;central nervous system;structure-function relationship;wounds healing"@en . . . "A number of current therapeutic drugs, as well as new substances being developed, affect the two main systems involved in the defence ot the living organisms. Both the nervous and immune systems, despite their autonomy, closaly cooperate, and a disease of one system very often causes disorders in the other system. The aim of the project is to better understand the relationship between these two systems and the possibilities for their pharmacological treatment. The other goal is to study the mechanism underlying the effect of therapeutic drugs and foreign substances on molecular and receptor levels and their genotoxic effects, for more rational use of the pharmacotherapeutical effects of these substances in clinical practice. Finally, the attention will be devoted a) to the effect of drugs on the striking power of the organism, b) the development of drugs with the influence on metabotropic glutamate receptors, c) the examination of enzymatic inhibitors with the aim to improve healing."@en . . . "0"^^ . . . "\u0158ada st\u00E1vaj\u00EDc\u00EDch farmak, ale i nov\u011B vyv\u00EDjen\u00FDch l\u00E1tek, p\u016Fsob\u00ED na oba hlavn\u00ED syst\u00E9my, hraj\u00EDc\u00ED kl\u00ED\u010Dovou \u00FAlohu v obran\u011B organismu. Oba syst\u00E9my, tj. centr\u00E1ln\u00ED nervov\u00FD a imunitn\u00ED, p\u0159es ur\u010Ditou autonomii spolu vz\u00E1jemn\u011B \u00FAzce komunikuj\u00ED a onemocn\u011Bn\u00ED jednoho syst\u00E9mu zp\u016Fsobuje \u010Dasto i poruchy v syst\u00E9mu druh\u00E9m. C\u00EDlem projektu je bl\u00ED\u017Ee porozum\u011Bt vz\u00E1jemn\u00E9 z\u00E1vislosti obou t\u011Bchto syst\u00E9m\u016F a mo\u017Enosti jejich farmakologick\u00E9ho ovlivn\u011Bn\u00ED. Dal\u0161\u00EDm c\u00EDlem je studium mechanismu \u00FA\u010Dinku farmak a cizorod\u00FDch l\u00E1tek na molekul\u00E1rn\u00ED a receptorov\u00E9 \u00FArovni a jejich genotoxick\u00FDch \u00FA\u010Dink\u016F za \u00FA\u010Delem racion\u00E1ln\u011Bj\u0161\u00EDho vyu\u017Eit\u00ED farmakoterapeutick\u00FDch \u00FA\u010Dink\u016F t\u011Bchto l\u00E1tek v klinick\u00E9 praxi. Kone\u010Dn\u011B pozornost bude v\u011Bnov\u00E1na a) vlivu farmak na aktivitu faktor\u016F, kter\u00E9 maj\u00ED kl\u00ED\u010Dov\u00FD v\u00FDznam v obranyschopnosti organizmu, b) v\u00FDvoji nov\u00FDch l\u00E9\u010Div p\u016Fsob\u00EDc\u00EDch na metabotropn\u00ED glutam\u00E1tov\u00E9 receptory a c) vy\u0161et\u0159en\u00ED vhodn\u00FDch enzymatick\u00FDch inhibitor\u016F s c\u00EDlem zlep\u0161it hojiv\u00E9 procesy." .