. . . "Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions"@en . . "2014-06-17+02:00"^^ . . . . "genome; epigenome; proteome; dynamics of biomolecules; DNA-protein interactions; posttranslational modifications; gene expression; DNA damage and repair; cellular signaling; redox equilibrium; carcinogenesis; phylogeny; biosensors; imaging techniques"@en . "722"^^ . "0"^^ . . . . "1"^^ . "722"^^ . . . . "The research will be focused on study of molecular and spatial structure of genome, effects of epigenetic variations on arrangement of the genome in cell nucleus, dynamics of genome, epigenome and proteome during cell cycle, differentiation and malignant transformation of the cell. We will investigate mechanisms of epigenetic control of gene expression and role of the epigenome in heredity of transcriptional profile and its changes in differentiation, ontogenesis and phylogeny. Attention will be paid to detailed study of the impacts of living systems exposure to external factors (physical and/or chemical) on genome, epigenome, transcriptome, proteome and metabolome levels. Efforts aimed to expansion of methodological background of the science disciplines involved, including development of novel experimental approaches, represent important strand of the proposed research. Results of the research plan will find applications especially in biomedicine, biotechnologies and ekotoxicology."@en . . . "2013-11-29+01:00"^^ . "V\u00FDzkum bude zam\u011B\u0159en na studium molekul\u00E1rn\u00ED a prostorov\u00E9 struktury genomu, vlivu epigenetick\u00FDch variac\u00ED na uspo\u0159\u00E1d\u00E1n\u00ED genomu v j\u00E1d\u0159e bu\u0148ky, dynamiky genomu, epigenomu a proteomu v pr\u016Fb\u011Bhu bun\u011B\u010Dn\u00E9ho cyklu, diferenciace a zhoubn\u00E9 transformace bu\u0148ky. Budou zkoum\u00E1ny mechanismy epigenetick\u00E9 regulace genov\u00E9 exprese a \u00FAloha epigenomu v d\u011Bdi\u010Dnosti transkrip\u010Dn\u00EDho profilu a jeho zm\u011Bn\u00E1ch p\u0159i diferenciaci, v ontogenezi a vn\u011Bj\u0161\u00EDm faktor\u016Fm (fyzik\u00E1ln\u00EDm a chemick\u00FDm) na \u00FArovni genomu, epigenomu, transkriptomu, proteomu a metabolomu. D\u016Fle\u017Eitou sou\u010D\u00E1st\u00ED navrhovan\u00E9ho v\u00FDzkumu bude roz\u0161i\u0159ov\u00E1n\u00ED metodologick\u00E9 v\u00FDbavy zahrnut\u00FDch v\u011Bdn\u00EDch obor\u016F, v\u010Detn\u011B v\u00FDvoje a zav\u00E1d\u011Bn\u00ED nov\u00FDch experiment\u00E1ln\u00EDch p\u0159\u00EDstup\u016F a analytick\u00FDch n\u00E1stroj\u016F. V\u00FDsledky \u0159e\u0161en\u00ED v\u00FDzkumn\u00E9ho z\u00E1m\u011Bru naleznou uplatn\u011Bn\u00ED zejm\u00E9na v biomedic\u00EDn\u011B, zem\u011Bd\u011Blsk\u00FDch biotechnologi\u00EDch a ekotoxikologii." . . "0"^^ . "2013-12-31+01:00"^^ . "Genom a epigenom: 1D a 3D struktura, dynamika, interakce s proteiny a funkce" . . . "2007-01-01+01:00"^^ . "The project has been oriented to the research of genome, its structure, dynamics and function and epigenome. It has been found a number of new and original results with marked international impact . The project contributed to the excellence of research of genome and epigenome in the Czech Republic, collaboration in this field of science and education of new scientists."@en . "V\u00FDzkumn\u00FD z\u00E1m\u011Br byl orientov\u00E1n na genom, jeho strukturu, dynamiku a funkci a epigenom. V r\u00E1mci jeho \u0159e\u0161en\u00ED byla nalezena a publikov\u00E1na \u0159ada nov\u00FDch, origin\u00E1ln\u00EDch v\u00FDsledk\u016F s velk\u00FDm mezin\u00E1rodn\u00EDm ohlasem (publikace dedikovan\u00E9 VZ byl doposud citov\u00E1ny 3350x). VZ p\u0159isp\u011Bl k pos\u00EDlen\u00ED excelence ve v\u00FDzkumu genomu a epigenomu v \u010CR, spolupr\u00E1ce v dan\u00E9 oblasti a v\u00FDchov\u011B nov\u00FDch v\u011Bdeck\u00FDch pracovn\u00EDk\u016F."@cs .