"Cells and biomolecules were investigated using biophysical methods. Original results on DNA structure and its interactions with proteins and pharmaceuticals, on the arrangement of the genome, DNA repair, on telomeres, cytokinetics, immune responses of cells, on evolution of sex chromosemes, epigenetics etc. were obtained. These results are important for both basic research and applications."@en . "896"^^ . "2012-07-03+02:00"^^ . . "2011-12-31+01:00"^^ . . "0"^^ . "V\u00FDzkum bude zam\u011B\u0159en na vztahy mezi prim\u00E1rn\u00ED strukturu DNA a jej\u00EDmi konforma\u010Dn\u00EDmi vlastnostmi, s ohledem na evoluci genom\u016F, interakce DNA s proteiny (histony, HMG proteiny, onkoproteiny) a s protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDmi l\u00E1tkami obsahuj\u00EDc\u00EDmi kovy, interakce DNA a protein\u016F v mezif\u00E1z\u00EDch ve vztahu k elektrochemick\u00FDch senzor\u016Fm pro genomiku a proteomiku, architekturu bun\u011B\u010Dn\u00E9ho j\u00E1dra, uspo\u0159\u00E1d\u00E1n\u00ED a modifikace chromatinu, strukturu a funkci nukleoprotein\u016F a telomerick\u00FDch komplex\u016F, dynamiku genom\u016F a genomov\u00FDch teritori\u00ED, vztahy mezi genovou expres\u00ED, bun\u011B\u010Dnou diferenciac\u00ED, onkogenn\u00ED transformac\u00ED a ontogenetick\u00FDm v\u00FDvojem, vliv endo- a exogenn\u00EDch medi\u00E1tor\u016F modifikuj\u00EDc\u00EDch proliferaci, diferenciaci a apopt\u00F3zu v bun\u011B\u010Dn\u00FDch populac\u00EDch, po\u010D\u00EDta\u010Dov\u00E9 simulace dynamick\u00E9 struktury a interakc\u00ED DNA/RNA s proteiny a biologicky aktivn\u00EDmi l\u00E1tkami. Aplikace budou sm\u011B\u0159ovat do medic\u00EDny, agrobiologie, ekotoxikologie a biotechnologi\u00ED." . "molecular dynamics; DNA-protein interactions; biosensors; anticancer drugs; HMG proteins; DNA-conformations; microsatelites; epigenetics; genome structure; nuclear architecture; cytokinins; cytokinetics; antioxidative processes; haematopoiesis"@en . . "1"^^ . . "Byly studov\u00E1ny bu\u0148ky a biomolekuly metodami biofyziky. Byly z\u00EDsk\u00E1ny origin\u00E1ln\u00ED poznatky o struktu\u0159e DNA a jejich interakc\u00EDch s proteiny nebo farmaky, o uspo\u0159\u00E1d\u00E1n\u00ED DNA v r\u00E1mci chromosom\u016F a genom\u016F, o reparaci DNA, telomer\u00E1ch chromosom\u016F, cytokinetice, imunitn\u00ED odpov\u011Bdi bun\u011Bk, evoluci pohlavn\u00EDch chromosom\u016F, epigenetice a dal\u0161\u00ED. Tyto poznatky jsou d\u016Fle\u017Eit\u00E9 pro z\u00E1kladn\u00ED v\u00FDzkum i pro aplikace."@cs . . . . . . "0"^^ . . . . "896"^^ . . "Research will be focused on: relations between the primary structure of the DNA and its conformational properties, with respect to evolution of genomes interactions of DNA with proteins (histones, HMG proteins, oncoproteins) and with metal-containing anticancer drugsinteractions of DNA and proteins in interphases in the relation to chemical sensors developed for genomics and proteomics the architecture of the cell nucleus, organisation and modifications of chromatin, structure and function of nucleoproteins and telomeric complexes, dynamics of genomes and genomic territories relations between gene expression, cell differentiation, oncogenic transformation and development effects of endo- and exogenous mediators modifying proliferation, differentiation and apoptosis in cell populations computer simulations of dynamic structures and interactions of DNA/RNA with proteins and biologically active compounds. Applications will be directed to medicine, agrobiology, ecotoxicology and biotechno"@en . "2011-12-06+01:00"^^ . "Biophysics of dynamic structures and functions of biological systems"@en . . . . "Biofyzika dynamick\u00FDch struktur a funkc\u00ED biologick\u00FDch syst\u00E9m\u016F" . "2005-01-01+01:00"^^ . .