"A functionally n gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in tumours. In addition to the presence of somatic mutations, polymorphic features of the gene may also contribute to alteration of the normal TP53 functioning and variants, mainly in the form of single nucleotide polymorphisms, can be expected to impact susceptibility to sporadic CRC. In the present study, we reviewed the potential role of alterations in the TP53 gene, both somatic mutations and inherited sequence variations, in predisposition to CRC and in the prognosis and response to therapy. The available data from association studies have mostly shown contradictory outcomes. The majority of the studies were based on limited sample sizes and focussed on a limited number of polymorphisms, with main b."@en . . . "I, P(GAP304/10/1286), P(GP305/09/P194), Z(AV0Z50390512)" . "10.1093/mutage/ger067" . . . . . "Vodi\u010Dkov\u00E1, Ludmila" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer" . . "7"^^ . "Pol\u00E1kov\u00E1, V." . "152547" . "Hemminki, K." . "Mutagenesis" . . "Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer"@en . . "RIV/75010330:_____/12:00009882" . "genetic polymorphisms; TP53 gene; colorectal cancer"@en . "1"^^ . "[A27A600F65AE]" . "Vodi\u010Dka, P." . . "Pardini, B." . . "Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer" . "000300040200010" . . . . "Kumar, R." . . "A functionally n gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in tumours. In addition to the presence of somatic mutations, polymorphic features of the gene may also contribute to alteration of the normal TP53 functioning and variants, mainly in the form of single nucleotide polymorphisms, can be expected to impact susceptibility to sporadic CRC. In the present study, we reviewed the potential role of alterations in the TP53 gene, both somatic mutations and inherited sequence variations, in predisposition to CRC and in the prognosis and response to therapy. The available data from association studies have mostly shown contradictory outcomes. The majority of the studies were based on limited sample sizes and focussed on a limited number of polymorphisms, with main b." . "Naccarati, A." . . . . "27" . "8"^^ . "Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer"@en . "2" . . "RIV/75010330:_____/12:00009882!RIV13-GA0-75010330" . "0267-8357" .