. "Pi\u0165ule, P." . . . "Moheln\u00EDkov\u00E1-Ducho\u0148ov\u00E1, Beatrice" . "The role of ABC transporters in progression and clinical outcome of colorectal cancer" . . "Bruha, J." . . . "The role of ABC transporters in progression and clinical outcome of colorectal cancer"@en . "12"^^ . "RIV/75010330:_____/12:00009720" . "Sou\u010Dek, Pavel" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Holubec, L." . . . "2" . . "The role of ABC transporters in progression and clinical outcome of colorectal cancer" . "10.1093/mutage/ger075" . "10"^^ . . "Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of cancer cells. The aim of this study was to explore transcript levels of all human ABCs in tumours and non-neoplastic control tissues from CRC patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen. The prognostic potential of ABCs was evaluated by the correlation of transcript levels with clinical factors. Relations between transcript levels of ABCs in tumours and chemotherapy efficacy were also addressed. The transcript profile of all known human ABCs was assessed using real-time polymerase chain reaction with a relative standard curve. The majority."@en . "colorectal cancer; ABC transporters"@en . "Nov\u00E1k, P." . "Vy\u010D\u00EDtal, O." . "P(GA310/07/1430), P(NS10230), S, Z(AV0Z50390512)" . "0267-8357" . . "Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of cancer cells. The aim of this study was to explore transcript levels of all human ABCs in tumours and non-neoplastic control tissues from CRC patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen. The prognostic potential of ABCs was evaluated by the correlation of transcript levels with clinical factors. Relations between transcript levels of ABCs in tumours and chemotherapy efficacy were also addressed. The transcript profile of all known human ABCs was assessed using real-time polymerase chain reaction with a relative standard curve. The majority." . . . . "Hlavat\u00E1, Ivona" . . "Vodi\u010Dka, P." . "Li\u0161ka, V." . . . "Mutagenesis" . . "The role of ABC transporters in progression and clinical outcome of colorectal cancer"@en . "4"^^ . . "000300040200007" . "V\u00E1clav\u00EDkov\u00E1, Radka" . . "T\u0159e\u0161ka, V." . "[977EA6FB6A2E]" . . "165963" . . "27" . "RIV/75010330:_____/12:00009720!RIV13-GA0-75010330" .