. . "Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data"@en . "Bendov\u00E1, Hana" . "251452" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "J\u00EDrov\u00E1, Dagmar" . "62" . "000274167800006" . . "RIV/75010330:_____/10:00008907!RIV11-MZ0-75010330" . . . . "[23590950B307]" . "Marriott, M." . . "8"^^ . . "3"^^ . "V" . "0105-1873" . "RIV/75010330:_____/10:00008907" . "Liebsch, M." . "Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data" . "7"^^ . . "Kejlov\u00E1, Kristina" . "Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data"@en . "Basketter, D." . . . . . "Kand\u00E1rov\u00E1, H." . "2" . "Contact dermatitis" . "Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity." . "Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data" . . . "Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity."@en . "skin irritation; skin; human epidermal model"@en .