"Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls. Three software tools successfully pointed to the overrepresentation of genes related to the mitogen-activated protein kinase (MAPK) signalling pathways among the 1340 most strongly associated markers from the GWAS (allelic P value 10)-3)). The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events (P-trend = 2.2 x 10(-16), ORper allele = 1.34, 95% CI 1.11-1.61)." . "31" . . "Gorgens, H." . "Morak, M." . . . "Kunkel, N." . "Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility" . "Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility"@en . "RIV/75010330:_____/10:00008887" . "Buch, S." . . "34"^^ . "0143-3334" . "Vodi\u010Dkov\u00E1, Ludmila" . "Goecke, T." . . . "Lascorz, J." . "Carcinogenesis" . "8"^^ . "Engel, C." . "[D59E02599AEE]" . . . "Weires, M." . "Holinski-Feder, E." . "Buttner, R." . "Steinke, V." . "Schulmann, K." . "Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls. Three software tools successfully pointed to the overrepresentation of genes related to the mitogen-activated protein kinase (MAPK) signalling pathways among the 1340 most strongly associated markers from the GWAS (allelic P value 10)-3)). The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events (P-trend = 2.2 x 10(-16), ORper allele = 1.34, 95% CI 1.11-1.61)."@en . "Hoffmeister, M." . "Naccarati, A." . "Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility"@en . "000281530400015" . "Chen, B. W." . "I, P(GA310/07/1430), Z(AV0Z50390512)" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Pardini, B." . . . "Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility" . . "260474" . "Forsti, A." . "colon cancer; genetic polymorphisms"@en . "RIV/75010330:_____/10:00008887!RIV13-GA0-75010330" . . "9" . "Kloor, M." . "Schackert, H. K." . . "1"^^ . . . "Rahner, N." .