"RIV/75010330:_____/09:00008403!RIV10-GA0-75010330" . "000264606100024" . . "European journal of cancer" . "Havr\u00E1nek, O." . "Hlavat\u00E1, Ivona" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . "[50D5A774D3F0]" . . . "The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population" . "Kleibl, Z." . "306872" . "Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population." . . . "45" . "7"^^ . "P(GA310/07/1430), Z(MSM0021620808)" . "Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population."@en . "0959-8049" . . "Checkpoint kinase 2 (CHEK2, CHK2); colorectal cancer; germ-line mutation; genetic screening; genetic predisposition; risk assessment"@en . "4" . "The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population" . . . . . . "The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population"@en . "7"^^ . "Sou\u010Dek, Pavel" . "The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population"@en . . "2"^^ . . . "\u0160ev\u010D\u00EDk, J." . . "RIV/75010330:_____/09:00008403" . "Novotn\u00FD, J." . . . "Pohlreich, P." . .