. "\u00DAvod: Pr\u00E1ce pojedn\u00E1v\u00E1 o vyu\u017Eit\u00ED rekurentn\u00ED anal\u00FDzy variability srde\u010Dn\u00ED frekvence (RQA) v \u010Dasn\u00E9 diagnostice diabetick\u00E9 autonomn\u00ED neuropatie. Kardiovaskul\u00E1rn\u00ED forma diabetick\u00E9 neuropatie je nejz\u00E1va\u017En\u011Bj\u0161\u00ED autonomn\u00ED komplikac\u00ED diabetu typu I. i II. s vysokou morbiditou a mortalitou. Jej\u00ED diagnostika v subklinick\u00E9m stadiu p\u0159isp\u00EDv\u00E1 k optimalizaci l\u00E9\u010Dby. V sou\u010Dasnosti se v diagnostice diabetick\u00E9 autonomn\u00ED neuropatie uplat\u0148uj\u00ED funk\u010Dn\u00ED testy vy\u0161et\u0159uj\u00EDc\u00ED dynamiku kardiovaskul\u00E1rn\u00EDho syst\u00E9mu p\u0159i vertikalizaci a b\u011Bhem dechov\u00FDch test\u016F. Z\u00E1znam R-R interval\u016F je analyzov\u00E1n v \u010Dasov\u00E9 a frekven\u010Dn\u00ED dom\u00E9n\u011B (spektr\u00E1ln\u00ED anal\u00FDza), st\u00E1le \u010Dast\u011Bji se v\u0161ak u\u017E\u00EDvaj\u00ED metody neline\u00E1rn\u00ED anal\u00FDzy schopn\u00E9 l\u00E9pe popsat chaotick\u00FD syst\u00E9m nad\u0159azen\u00E9 kontroly srde\u010Dn\u00EDho rytmu. V\u00FDhodou metody, popisovanou v literatu\u0159e, je vy\u0161\u0161\u00ED citlivost, odolnost v\u016F\u010Di artefakt\u016Fm a mo\u017Enost aplikace na krat\u0161\u00ED z\u00E1znamy EKG, u kter\u00FDch jsou standardn\u00ED metody anal\u00FDzy nepou\u017Eiteln\u00E9. Metodika: Pou\u017Eili jsme RQA p\u0159i ortostatick\u00E9m testu (leh-stoj) u skupiny 19 uspokojiv\u011B kompenzovan\u00FDch diabetik\u016F II. typu ve v\u011Bku 50-62 let bez p\u0159\u00EDznak\u016F autonomn\u00ED neuropatie. Hodnoceny byly 4 parametry RQA - determinismus, laminarita, Lmax a trapping time. V\u00FDsledky byly srovn\u00E1ny s v\u011Bkov\u011B odpov\u00EDdaj\u00EDc\u00ED skupinou zdrav\u00FDch kontrol. V\u00FDsledky: Byly prok\u00E1z\u00E1ny signifikantn\u00ED rozd\u00EDly parametr\u016F determinismus (p=0,0001), laminarita (p=0,0002), Lmax (p=0,026) a trapping time (p = 0,0214) mezi skupinami. N\u00E1sledn\u011B byly srovn\u00E1ny vybran\u00E9 parametry rekurentn\u00ED, \u010Dasov\u00E9 a spektr\u00E1ln\u00ED anal\u00FDzy v obou f\u00E1z\u00EDch ortostatick\u00E9 zkou\u0161ky. Z\u00E1v\u011Br: P\u0159i porovn\u00E1n\u00ED parametr\u016F rekurentn\u00ED anal\u00FDzy u diabetik\u016F a kontrol byly zji\u0161t\u011Bny signifikantn\u00ED rozd\u00EDly mezi ob\u011Bma skupinami, sv\u011Bd\u010D\u00EDc\u00ED pro vy\u0161\u0161\u00ED rekurenci R-R interval\u016F a simplifikaci z\u00E1znamu variability srde\u010Dn\u00ED frekvence u diabetik\u016F. P\u0159i vz\u00E1jemn\u00E9m porovn\u00E1n\u00ED statistick\u00E9 hladiny v\u00FDznamnosti vybran\u00FDch parametr\u016F rekurentn\u00ED, frekven\u010Dn\u00ED a \u010Dasov\u00E9 anal\u00FDzy bylo zji\u0161t\u011Bno, \u017Ee RQA disponuje velmi vysokou senzitivitou. RQA by proto mohla b\u00FDt p\u0159\u00EDnosn\u00FDm dopl\u0148kem" . "\u00DAvod: Pr\u00E1ce pojedn\u00E1v\u00E1 o vyu\u017Eit\u00ED rekurentn\u00ED anal\u00FDzy variability srde\u010Dn\u00ED frekvence (RQA) v \u010Dasn\u00E9 diagnostice diabetick\u00E9 autonomn\u00ED neuropatie. Kardiovaskul\u00E1rn\u00ED forma diabetick\u00E9 neuropatie je nejz\u00E1va\u017En\u011Bj\u0161\u00ED autonomn\u00ED komplikac\u00ED diabetu typu I. i II. s vysokou morbiditou a mortalitou. Jej\u00ED diagnostika v subklinick\u00E9m stadiu p\u0159isp\u00EDv\u00E1 k optimalizaci l\u00E9\u010Dby. V sou\u010Dasnosti se v diagnostice diabetick\u00E9 autonomn\u00ED neuropatie uplat\u0148uj\u00ED funk\u010Dn\u00ED testy vy\u0161et\u0159uj\u00EDc\u00ED dynamiku kardiovaskul\u00E1rn\u00EDho syst\u00E9mu p\u0159i vertikalizaci a b\u011Bhem dechov\u00FDch test\u016F. Z\u00E1znam R-R interval\u016F je analyzov\u00E1n v \u010Dasov\u00E9 a frekven\u010Dn\u00ED dom\u00E9n\u011B (spektr\u00E1ln\u00ED anal\u00FDza), st\u00E1le \u010Dast\u011Bji se v\u0161ak u\u017E\u00EDvaj\u00ED metody neline\u00E1rn\u00ED anal\u00FDzy schopn\u00E9 l\u00E9pe popsat chaotick\u00FD syst\u00E9m nad\u0159azen\u00E9 kontroly srde\u010Dn\u00EDho rytmu. V\u00FDhodou metody, popisovanou v literatu\u0159e, je vy\u0161\u0161\u00ED citlivost, odolnost v\u016F\u010Di artefakt\u016Fm a mo\u017Enost aplikace na krat\u0161\u00ED z\u00E1znamy EKG, u kter\u00FDch jsou standardn\u00ED metody anal\u00FDzy nepou\u017Eiteln\u00E9. Metodika: Pou\u017Eili jsme RQA p\u0159i ortostatick\u00E9m testu (leh-stoj) u skupiny 19 uspokojiv\u011B kompenzovan\u00FDch diabetik\u016F II. typu ve v\u011Bku 50-62 let bez p\u0159\u00EDznak\u016F autonomn\u00ED neuropatie. Hodnoceny byly 4 parametry RQA - determinismus, laminarita, Lmax a trapping time. V\u00FDsledky byly srovn\u00E1ny s v\u011Bkov\u011B odpov\u00EDdaj\u00EDc\u00ED skupinou zdrav\u00FDch kontrol. V\u00FDsledky: Byly prok\u00E1z\u00E1ny signifikantn\u00ED rozd\u00EDly parametr\u016F determinismus (p=0,0001), laminarita (p=0,0002), Lmax (p=0,026) a trapping time (p = 0,0214) mezi skupinami. N\u00E1sledn\u011B byly srovn\u00E1ny vybran\u00E9 parametry rekurentn\u00ED, \u010Dasov\u00E9 a spektr\u00E1ln\u00ED anal\u00FDzy v obou f\u00E1z\u00EDch ortostatick\u00E9 zkou\u0161ky. Z\u00E1v\u011Br: P\u0159i porovn\u00E1n\u00ED parametr\u016F rekurentn\u00ED anal\u00FDzy u diabetik\u016F a kontrol byly zji\u0161t\u011Bny signifikantn\u00ED rozd\u00EDly mezi ob\u011Bma skupinami, sv\u011Bd\u010D\u00EDc\u00ED pro vy\u0161\u0161\u00ED rekurenci R-R interval\u016F a simplifikaci z\u00E1znamu variability srde\u010Dn\u00ED frekvence u diabetik\u016F. P\u0159i vz\u00E1jemn\u00E9m porovn\u00E1n\u00ED statistick\u00E9 hladiny v\u00FDznamnosti vybran\u00FDch parametr\u016F rekurentn\u00ED, frekven\u010Dn\u00ED a \u010Dasov\u00E9 anal\u00FDzy bylo zji\u0161t\u011Bno, \u017Ee RQA disponuje velmi vysokou senzitivitou. RQA by proto mohla b\u00FDt p\u0159\u00EDnosn\u00FDm dopl\u0148kem"@cs . "Ned\u011Blka, Tom\u00E1\u0161" . . "75" . "Mazanec, R." . . . . "I, S" . . . "RIV/68407700:21460/12:00197590!RIV13-MSM-21460___" . "Recurrence analysis of heart rate variability in the early diagnosis of diabetic autonomic neuropathy"@en . "Recurrence analysis of heart rate variability in the early diagnosis of diabetic autonomic neuropathy"@en . . "4"^^ . "Riedlbauchov\u00E1, L." . "[6A1424BA4CFF]" . "164785" . "Rekurentn\u00ED anal\u00FDza variability srde\u010Dn\u00ED frekvence v \u010Dasn\u00E9 diagnostice diabetick\u00E9 autonomn\u00ED neuropatie"@cs . . . "http://www.csnn.eu/ceska-slovenska-neurologie-clanek/rekurentni-analyza-variability-srdecni-frekvence-v-casne-diagnostice-diabeticke-autonomni-neuropatie-38956" . "\u010Cesk\u00E1 a Slovensk\u00E1 neurologie a neurochirurgie" . . "6" . . . "2"^^ . . "diabetic autonomic neuropathy; cardial autonomic neuropathy; diabetes mellitus; heart rate variability; spectral analysis; recurrence analysis; recurrent graph; RQA; functional tests"@en . "CZ - \u010Cesk\u00E1 republika" . . . "RIV/68407700:21460/12:00197590" . "Rekurentn\u00ED anal\u00FDza variability srde\u010Dn\u00ED frekvence v \u010Dasn\u00E9 diagnostice diabetick\u00E9 autonomn\u00ED neuropatie" . . "Schlenker, Jakub" . . "Rekurentn\u00ED anal\u00FDza variability srde\u010Dn\u00ED frekvence v \u010Dasn\u00E9 diagnostice diabetick\u00E9 autonomn\u00ED neuropatie"@cs . "Introduction: Detection of autonomic dysfunction in subclinical stages of diabetic cardiovascular autonomic neuropathy is highly important, and helps in risk stratification and therapy management. Evaluation of cardiovascular function is usually based on heart rate variability (HRV) linear data analysis in time and frequency domains. However, superior autonomic control of heart rate is complex and could be described by non-linear analysis. Recurrence quantification analysis (RQA) used in our study is non-linear method evaluating recurrences of heart rates that is applicable also in shorter recordings and in non-stationary data, where the linear methods are unapplicable. Methods: We analysed R-R intervals (interval between two ventricular complexes) RQA during orthostatic test (5 minutes supine rest with following 5 minutes stand-up phase) in 20 patients with type II diabetes (mean age 54 years). Results were compared to sex and age-matched group of 19 healthy controls (mean age 52 years). Cross-comparison between RQA, time- and frequency-domains analysis during the supine rest phase of orthostatic test was also performed. Results: There was significant increase in percentage of recurrences in diabetic patients compared to controls in parameters: determinism (p = 0.0001), laminarity (p = 0.0002), Lmax (p = 0.026) and trapping time (p = 0.0214) in both phases of orthostatic test. In supine rest phase, we found significant increase in determinism, laminarity and trapping time. However, parameter L max remained unsignificant compared to control group and results were similar to previous studies. Conclusion: Reduction of complexity in cardiovascular regulation in diabetic patients compared to age-matched controls was found. In comparison to standard methods for autonomic function evaluation, RQA appears to be more sensitive in diagnostics of subclinical cardiovascular autonomic neuropathy. RQA may have additive value to time and frequency domain analysis of HRV."@en . . "21460" . "1802-4041" . . "8"^^ . . . . "Rekurentn\u00ED anal\u00FDza variability srde\u010Dn\u00ED frekvence v \u010Dasn\u00E9 diagnostice diabetick\u00E9 autonomn\u00ED neuropatie" .