. "2" . . "Kurey, Irina" . "I, P(GA310/08/1697), P(LH12049)" . "Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics"@en . . "Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics" . . "Gusareva, Elena" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody."@en . "RIV/68378050:_____/14:00434619!RIV15-GA0-68378050" . . . . "Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody." . . . . "31"^^ . "Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics"@en . "[88742F7DEA70]" . . "Lipoldov\u00E1, Marie" . . "10.1111/brv.12059" . "89" . "000334182600007" . . . "Genetic control of complex diseases; Immunoglobulin E; Epistasis"@en . . "4"^^ . "1464-7931" . "4"^^ . "Biological Reviews" . "Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics" . . . . "RIV/68378050:_____/14:00434619" . "18101" . . "Grekov, Igor" .