"RIV/68378050:_____/14:00431703" . . "nuclear gems; SMN; U1-70K"@en . "Stejskalov\u00E1, Eva" . . "The nuclear SMN complex localizes to specific structures called nuclear gems. The loss of gems is a cellular marker for several neurodegenerative diseases. Here, we identify that the U1-snRNP-specific protein U1-70K localizes to nuclear gems, and we show that U1-70K is necessary for gem integrity. Furthermore, we show that the interaction between U1-70K and the SMN complex is RNA independent, and we map the SMN complex binding site to the unstructured N-terminal tail of U1-70K. Consistent with these results, the expression of the U1-70K N-terminal tail rescues gem formation. These findings show that U1-70K is an SMN-complex-associating protein, and they suggest a new function for U1-70K in the formation of nuclear gems." . . . . . . "The nuclear SMN complex localizes to specific structures called nuclear gems. The loss of gems is a cellular marker for several neurodegenerative diseases. Here, we identify that the U1-snRNP-specific protein U1-70K localizes to nuclear gems, and we show that U1-70K is necessary for gem integrity. Furthermore, we show that the interaction between U1-70K and the SMN complex is RNA independent, and we map the SMN complex binding site to the unstructured N-terminal tail of U1-70K. Consistent with these results, the expression of the U1-70K N-terminal tail rescues gem formation. These findings show that U1-70K is an SMN-complex-associating protein, and they suggest a new function for U1-70K in the formation of nuclear gems."@en . . . . . "0021-9533" . . "Journal of Cell Science" . "I, P(GAP302/11/1910)" . "2"^^ . "000342357900005" . "RIV/68378050:_____/14:00431703!RIV15-GA0-68378050" . "18" . . "The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "46664" . "7"^^ . "Stan\u011Bk, David" . "2"^^ . "The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity" . "127" . . "The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity"@en . "[82127FD7E30B]" . . "The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity"@en . . "10.1242/jcs.155838" . .