"US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "7"^^ . . "1547-3287" . "Proch\u00E1zkov\u00E1, Jana" . "6" . "Tro\u0161an, Peter" . . "P(1M0506), P(GAP301/11/1568), P(GAP304/11/0653), P(GD310/08/H077), P(KAN200520804), S, Z(AV0Z50520514), Z(MSM0021620858)" . "The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population" . . . . "Svobodov\u00E1, Eli\u0161ka" . "000302222700008" . "Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-\u03B2 and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and ROR\u03B3t and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions."@en . . . "Pokorn\u00E1, Kate\u0159ina" . "Zaj\u00EDcov\u00E1, Alena" . . "The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population"@en . "RIV/68378050:_____/12:00375938!RIV13-GA0-68378050" . . . "Hol\u00E1\u0148, Vladim\u00EDr" . "The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population" . . "Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-\u03B2 and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and ROR\u03B3t and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions." . . "RIV/68378050:_____/12:00375938" . . "Stem Cells and Development" . . . "10.1089/scd.2011.0157" . "10"^^ . "21" . . . . "[3DA972C888C9]" . . . . . "166033" . . . . . "mesenchymal stem cells; immunomodulation; T-cell development"@en . "7"^^ . . . . "The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population"@en . "Krulov\u00E1, Magdalena" .