"P(GA301/07/1410), P(GA301/09/1024), P(GAP301/10/2174), Z(AV0Z50520514)" . . "5-azacytidine; MHC class I downregulation; tumour chemoimmunotherapy"@en . . . . "Reini\u0161, Milan" . . "Indrov\u00E1, Marie" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "[1FB020158141]" . . . . . "British Journal of Cancer" . "RIV/68378050:_____/11:00371265" . "0007-0920" . . "10" . "Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status"@en . "Poll\u00E1kov\u00E1, Veronika" . "Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status" . . . "\u0160t\u011Bp\u00E1nek, Ivan" . "10.1038/bjc.2011.428" . . "Bieblov\u00E1, Jana" . . "9"^^ . . . . "RIV/68378050:_____/11:00371265!RIV12-AV0-68378050" . "8"^^ . . "Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status"@en . "Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status" . "Buben\u00EDk, Jan" . . "8"^^ . . "000296794200009" . "105" . "We evaluated the anti-tumour effects of the DNA methyltransferase inhibitor 5-azacytidine (5AC) The 5AC therapy was combined with immunotherapy, using a murine model for HPV16-associated tumours. We have demonstrated 5AC additive effects against MHC class I-positive and -deficient tumours when combined with unmethylated CpG oligodeoxynucleotides (CpG ODN) or with IL-12-producing cellular vaccine. The efficacy of the combined chemoimmunotherapy against originally MHC class I-deficient tumours was partially dependent on the CD8+-mediated immune responses. Increased cell surface expression of MHC class I cell molecules, associated with upregulation of the antigen-presenting machinery-related genes, as well as of genes encoding selected components of the IFN\u03B3 signalling pathway in tumours explanted from 5AC-treated animals, were observed." . "Miky\u0161kov\u00E1, Romana" . . "203612" . . . "\u0160\u00EDmov\u00E1, Jana" . . "We evaluated the anti-tumour effects of the DNA methyltransferase inhibitor 5-azacytidine (5AC) The 5AC therapy was combined with immunotherapy, using a murine model for HPV16-associated tumours. We have demonstrated 5AC additive effects against MHC class I-positive and -deficient tumours when combined with unmethylated CpG oligodeoxynucleotides (CpG ODN) or with IL-12-producing cellular vaccine. The efficacy of the combined chemoimmunotherapy against originally MHC class I-deficient tumours was partially dependent on the CD8+-mediated immune responses. Increased cell surface expression of MHC class I cell molecules, associated with upregulation of the antigen-presenting machinery-related genes, as well as of genes encoding selected components of the IFN\u03B3 signalling pathway in tumours explanted from 5AC-treated animals, were observed."@en . . .