. . . "AU - Australsk\u00E9 spole\u010Denstv\u00ED" . "Phlebotomus duboscqi; Leishmania major; anti-saliva IgG"@en . . "[60AB8E4D03CB]" . "2"^^ . "224808" . "P(GA206/09/0777), P(GA206/09/0822), P(LC06009), S, Z(AV0Z50520514), Z(MSM0021620828)" . . "000289402300002" . . "Kobets, Tetyana" . . . "Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva." . . . "41" . "The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure"@en . "Volf, P." . . "RIV/68378050:_____/11:00365117" . "The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure" . "Hostomsk\u00E1, J." . "The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure"@en . . . . "Rohou\u0161ov\u00E1, I." . "RIV/68378050:_____/11:00365117!RIV12-AV0-68378050" . "5"^^ . . . "10.1016/j.ijpara.2011.01.003" . "The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure" . . . "Vlkov\u00E1, M." . . "Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva."@en . "0020-7519" . . . . "International Journal for Parasitology" . . "6"^^ . "5" . "Lipoldov\u00E1, Marie" .