. "53" . . . . "1"^^ . "Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic AnhydraseInhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies"@en . . "8"^^ . "Agnello, S." . . . "Ferro, S." . "Chimirri, A." . "Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic AnhydraseInhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies"@en . "This work explores inhibitory effects a small class of 1-(cyclo)alkylisoquinolines containing a sulfonamide function on the activity of carbonic anhydrase (CA, EC 4.2.1.1). Some derivatives showed potent hCA IX and hCA XIV inhibitory effects at nanomolar concentrations as well as low affinity for the ubiquitous hCA II. We also report the X-ray crystal structure of one of these derivatives in complex with dominant human isoform II."@en . . "6" . "Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic AnhydraseInhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies" . "RIV/68378050:_____/10:00343450!RIV11-GA0-68378050" . "This work explores inhibitory effects a small class of 1-(cyclo)alkylisoquinolines containing a sulfonamide function on the activity of carbonic anhydrase (CA, EC 4.2.1.1). Some derivatives showed potent hCA IX and hCA XIV inhibitory effects at nanomolar concentrations as well as low affinity for the ubiquitous hCA II. We also report the X-ray crystal structure of one of these derivatives in complex with dominant human isoform II." . "Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic AnhydraseInhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies" . . "0022-2623" . "Vullo, D." . . . "inhibitor design; crystal structure; X-ray analysis; dehalogenase"@en . . "Gitto, R." . "De Luca, L." . . . . "Mader, Pavel" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "000275711000008" . . "Journal of Medicinal Chemistry" . . "Brynda, Ji\u0159\u00ED" . "RIV/68378050:_____/10:00343450" . "[DA0EE82737B1]" . "P(GA203/09/0820), Z(AV0Z40550506), Z(AV0Z50520514)" . "9"^^ . . . "262732" . "Supuran, C. T." .