"Sohrabi, Yahya" . . "Tumor susceptibility; Genetic control of interferon gamma production; Lymphocyte infiltration of tumors"@en . . . "Stassen, A. P. M." . "[514FCA4AB3BD]" . "9"^^ . . "Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility" . . . "Demant, P." . "Havelkov\u00E1, Helena" . "Vojt\u00ED\u0161kov\u00E1, Jarmila" . "RIV/68378050:_____/10:00334121" . "0340-7004" . "6"^^ . . . . "2" . "Quan, L." . . . "Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth."@en . . . "RIV/68378050:_____/10:00334121!RIV10-MSM-68378050" . . "Krulov\u00E1, Magdalena" . "Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth." . "Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility"@en . . "Sohrabi, Yahya" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "11"^^ . . "Lipoldov\u00E1, Marie" . . "Badalov\u00E1, Jana" . "268776" . . . . "Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility" . "Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility"@en . "P(GD310/08/H077), P(IAA500520606), P(LC06009), Z(AV0Z50520514)" . "Cancer Immunology and Immunotherapy" . . . . "000271748600003" . "59" .