"Preparation of recombinant intracellular part of protein OPAL1"@en . . "realiz\u00E1tor Apronex s.r.o., I\u010C 27093123" . "OPAL1; leukemia; recombinant protein; expression plasmid"@en . "Ho\u0159ej\u0161\u00ED, V\u00E1clav" . "RIV/68378050:_____/09:00355221" . . "336199" . "v\u00FDsledek p\u0159ipraven ke komer\u010Dn\u00EDmu vyu\u017Eit\u00ED na z\u00E1klad\u011B smlouvy o p\u0159ed\u00E1n\u00ED v\u00FDsledku realiz\u00E1torovi" . . "P\u0159\u00EDprava rekombinantn\u00ED intracelul\u00E1rn\u00ED \u010D\u00E1sti proteinu OPAL1"@cs . . . . . "P\u0159\u00EDprava rekombinantn\u00ED intracelul\u00E1rn\u00ED \u010D\u00E1sti proteinu OPAL1"@cs . "[9739393BE13E]" . . . . "1"^^ . . "Rekombinantn\u00ED intracelul\u00E1rn\u00ED \u010D\u00E1st proteinu OPAL1, v\u00FDsledek ov\u011B\u0159en pro zaveden\u00ED do v\u00FDroby" . . . . "OPAL1 je transmembr\u00E1nov\u00FD adaptorov\u00FD protein exprimovan\u00FD zejm\u00E9na megakaryocyty a krevn\u00EDmi desti\u010Dkami. Jeho exprese je zv\u00FD\u0161en\u00E1 u TEL/AML pozitivn\u00EDch leukemi\u00ED. Kvalitn\u00ED monoklon\u00E1ln\u00ED protil\u00E1tky proti tomuto d\u016Fle\u017Eit\u00E9mu proteinu nejsou v sou\u010Dasn\u00E9 dob\u011B k dispozici. Byl p\u0159ipraven expresn\u00ED konstrukt umo\u017E\u0148uj\u00EDc\u00ED bakteri\u00E1ln\u00ED expresi cytoplasmatick\u00E9 \u010D\u00E1sti proteinu OPAL1. Protein byl vypurifikov\u00E1n z bakteri\u00E1ln\u00EDho lyz\u00E1tu pomoc\u00ED afinitn\u00ED chromatografie. T\u00EDmto rekombinantn\u00EDmi proteinem je mo\u017En\u00E9 imunizovat pokusn\u00E1 zv\u00ED\u0159ata za \u00FA\u010Delem z\u00EDsk\u00E1in\u00ED monoklon\u00E1ln\u00EDch protil\u00E1tek. Je vhodn\u00FD i pro rutinn\u00ED testov\u00E1n\u00ED kvality produkovan\u00FDch protil\u00E1tek metodou ELISA." . . . "1"^^ . . . "P(2B06064), Z(AV0Z50520514)" . . "P\u0159\u00EDprava rekombinantn\u00ED intracelul\u00E1rn\u00ED \u010D\u00E1sti proteinu OPAL1" . "P\u0159\u00EDprava rekombinantn\u00ED intracelul\u00E1rn\u00ED \u010D\u00E1sti proteinu OPAL1" . . "OPAL1 je transmembr\u00E1nov\u00FD adaptorov\u00FD protein exprimovan\u00FD zejm\u00E9na megakaryocyty a krevn\u00EDmi desti\u010Dkami. Jeho exprese je zv\u00FD\u0161en\u00E1 u TEL/AML pozitivn\u00EDch leukemi\u00ED. Kvalitn\u00ED monoklon\u00E1ln\u00ED protil\u00E1tky proti tomuto d\u016Fle\u017Eit\u00E9mu proteinu nejsou v sou\u010Dasn\u00E9 dob\u011B k dispozici. Byl p\u0159ipraven expresn\u00ED konstrukt umo\u017E\u0148uj\u00EDc\u00ED bakteri\u00E1ln\u00ED expresi cytoplasmatick\u00E9 \u010D\u00E1sti proteinu OPAL1. Protein byl vypurifikov\u00E1n z bakteri\u00E1ln\u00EDho lyz\u00E1tu pomoc\u00ED afinitn\u00ED chromatografie. T\u00EDmto rekombinantn\u00EDmi proteinem je mo\u017En\u00E9 imunizovat pokusn\u00E1 zv\u00ED\u0159ata za \u00FA\u010Delem z\u00EDsk\u00E1in\u00ED monoklon\u00E1ln\u00EDch protil\u00E1tek. Je vhodn\u00FD i pro rutinn\u00ED testov\u00E1n\u00ED kvality produkovan\u00FDch protil\u00E1tek metodou ELISA."@cs . . "Preparation of recombinant intracellular part of protein OPAL1"@en . "OPAL1 is a transmembrane adaptor protein expresed especially by megakaryocytes and platelets. Its expression is increased in TEL/AML positive leukaemia. No good antibodies to OPAL1 are available. An expression construct was prepared suitable for bacterial expression of intracellular part of OPAL1. The protein was purified from bacterial lysate by affinity chromatography. and used for immunization of mice to prepare mnonoclonal antibodies (mAbs). The protein is a unique tool for immunization and testing of mAbs by ELISA."@en . "RIV/68378050:_____/09:00355221!RIV11-MSM-68378050" . "OPAL1" . .