. . . . "Ho\u0159ej\u0161\u00ED, V\u00E1clav" . . "P\u0159\u00EDprava monoklon\u00E1ln\u00EDch protil\u00E1tek proti receptorov\u00E9 tyrosinfosfatase CD148"@cs . "realiz\u00E1tor Apronex s.r.o., I\u010C 27093123" . "CD148; protein thyrosine phosphatase; hybridoma"@en . "MEM-CD148-04, -05" . . . . "RIV/68378050:_____/09:00355204!RIV11-MSM-68378050" . "P\u0159\u00EDprava monoklon\u00E1ln\u00EDch protil\u00E1tek proti receptorov\u00E9 tyrosinfosfatase CD148" . "RIV/68378050:_____/09:00355204" . "v\u00FDsledek p\u0159ipraven ke komer\u010Dn\u00EDmu vyu\u017Eit\u00ED na z\u00E1klad\u011B smlouvy o p\u0159ed\u00E1n\u00ED v\u00FDsledku realiz\u00E1torovi" . . . . "My\u0161\u00ED hybridomov\u00E9 bun\u011B\u010Dn\u00E9 linie produkuj\u00EDc\u00ED monoklon\u00E1ln\u00ED protil\u00E1tky MEM-CD148 rozpozn\u00E1vaj\u00EDc\u00ED tyrosinfosfatasu CD148, v\u00FDsledek ov\u011B\u0159en pro zaveden\u00ED do v\u00FDroby" . . "CD148 je receptorov\u00E1 protein tyrosin fosfatasa, kter\u00E1 je exprimov\u00E1na epiteli\u00E1ln\u00EDmi bu\u0148kami a r\u016Fzn\u00FDmi typy leukocyt\u016F. V epiteli\u00E1ln\u00EDch bu\u0148k\u00E1ch je zn\u00E1m\u00E1 jako n\u00E1dorov\u00FD supresor. Potenci\u00E1ln\u00ED funkce CD148 jako n\u00E1dorov\u00E9ho markeru nebo supresoru nebyla v leukemick\u00FDch bu\u0148k\u00E1ch studov\u00E1na. V sou\u010Dasn\u00E9 dob\u011B nejsou k dispozici kvalitn\u00ED protil\u00E1tky proti t\u00E9to molekule. V r\u00E1mci tohoto projektu jsme p\u0159ipravili s\u00E9rii monoklon\u00E1ln\u00EDch protil\u00E1tek proti tomuto proteinu. Protil\u00E1tka MEM-CD148-05 je dob\u0159e pou\u017Eiteln\u00E1 pro pr\u016Ftokovou cytometrii. Protil\u00E1tka MEM-CD148-04 je velmi kvalitn\u00ED reagenci\u00ED pro imunobloting. Tyto protil\u00E1tky budou firmou Apronex nab\u00EDzeny prost\u0159ednictv\u00EDm partnersk\u00FDch distribu\u010Dn\u00EDch firem. P\u0159ipraven\u00E9 protil\u00E1tky slou\u017E\u00ED k detekci receptorov\u00E9 protein tyrosin fosfatasy CD148 pomoc\u00ED imunoblotingu a pr\u016Ftokov\u00E9 cytometrie. Jsou tak z\u00E1kladn\u00EDm n\u00E1strojem studia exprese a funkce CD148 v lidsk\u00FDch bu\u0148k\u00E1ch v\u010Detn\u011B bun\u011Bk leukemick\u00FDch a odpov\u00EDdaj\u00EDc\u00EDch v\u00FDvojov\u00FDch stadi\u00EDch leukocyt\u016F."@cs . "Preparation of monoclonal antibodies to receptor phosphatase CD148"@en . . "1"^^ . "336188" . "P\u0159\u00EDprava monoklon\u00E1ln\u00EDch protil\u00E1tek proti receptorov\u00E9 tyrosinfosfatase CD148"@cs . . "P(2B06064), Z(AV0Z50520514)" . . "P\u0159\u00EDprava monoklon\u00E1ln\u00EDch protil\u00E1tek proti receptorov\u00E9 tyrosinfosfatase CD148" . "Preparation of monoclonal antibodies to receptor phosphatase CD148"@en . "CD148 je receptorov\u00E1 protein tyrosin fosfatasa, kter\u00E1 je exprimov\u00E1na epiteli\u00E1ln\u00EDmi bu\u0148kami a r\u016Fzn\u00FDmi typy leukocyt\u016F. V epiteli\u00E1ln\u00EDch bu\u0148k\u00E1ch je zn\u00E1m\u00E1 jako n\u00E1dorov\u00FD supresor. Potenci\u00E1ln\u00ED funkce CD148 jako n\u00E1dorov\u00E9ho markeru nebo supresoru nebyla v leukemick\u00FDch bu\u0148k\u00E1ch studov\u00E1na. V sou\u010Dasn\u00E9 dob\u011B nejsou k dispozici kvalitn\u00ED protil\u00E1tky proti t\u00E9to molekule. V r\u00E1mci tohoto projektu jsme p\u0159ipravili s\u00E9rii monoklon\u00E1ln\u00EDch protil\u00E1tek proti tomuto proteinu. Protil\u00E1tka MEM-CD148-05 je dob\u0159e pou\u017Eiteln\u00E1 pro pr\u016Ftokovou cytometrii. Protil\u00E1tka MEM-CD148-04 je velmi kvalitn\u00ED reagenci\u00ED pro imunobloting. Tyto protil\u00E1tky budou firmou Apronex nab\u00EDzeny prost\u0159ednictv\u00EDm partnersk\u00FDch distribu\u010Dn\u00EDch firem. P\u0159ipraven\u00E9 protil\u00E1tky slou\u017E\u00ED k detekci receptorov\u00E9 protein tyrosin fosfatasy CD148 pomoc\u00ED imunoblotingu a pr\u016Ftokov\u00E9 cytometrie. Jsou tak z\u00E1kladn\u00EDm n\u00E1strojem studia exprese a funkce CD148 v lidsk\u00FDch bu\u0148k\u00E1ch v\u010Detn\u011B bun\u011Bk leukemick\u00FDch a odpov\u00EDdaj\u00EDc\u00EDch v\u00FDvojov\u00FDch stadi\u00EDch leukocyt\u016F." . . "[CA2469A66494]" . . "1"^^ . . . . "CD148 ia a membrane phosphatase known in epithelial cells as a tumor suppressor. Nothing is known about potential tumor suppressor function of CD148 in leukocytes is known. No good commercial antibodies to CD148 exist. A series of monoclonal antibodies (mAbs) to CD148 was prepared. One of them, MEM-CD148-05 is suitable for cytofluorometry, MEM-CD148-04 is a very good reagent for immunobloting. These mAbs will be commercialized by the Apronex s.r.o. through distribution partner companies. The mAbs are useful for detection of receptor phosphatase CD148 by immunoblotting and cytofluorometry and therefore represent basic tools for examination of expression and function of CD148 in normal and leukemic human cells."@en . .