"Journal of Virology" . "In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens." . "9"^^ . "RIV/68378050:_____/09:00330753!RIV10-MSM-68378050" . "83" . . . "000269122300048" . . "1"^^ . "Brynda, Ji\u0159\u00ED" . "17" . . "[6BDCEE92438B]" . "\u0158ez\u00E1\u010Dov\u00E1, Pavl\u00EDna" . . . "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "0022-538X" . "RIV/68378050:_____/09:00330753" . . "HIV-1 protease; darunavir; X-ray structural analysis; protease inhibitor; mutations"@en . "Grantz \u0160a\u0161kov\u00E1, Kl\u00E1ra" . . "Yashina, T." . . "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir" . . . "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir"@en . "Kagan, R. M." . . . "Konvalinka, Jan" . "P(1M0508), Z(AV0Z40550506), Z(AV0Z50520514)" . . . . . "7"^^ . . "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir"@en . "In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens."@en . . "Ko\u017E\u00ED\u0161ek, Milan" . "327220" .