"Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces" . "Rho kinase ROCK; traction force microscopy; ameboid invasion"@en . . "Brabek, J." . "401600" . "1"^^ . "Srovn\u00E1vali jsme \u00FArove\u0148 sign\u00E1lu Rho/ROCK ve vysoce metastatick\u00FDch bu\u0148k\u00E1ch a v parent\u00E1ln\u00EDch bu\u0148k\u00E1ch bez metast\u00E1zovac\u00ED aktivity. Metastatick\u00E9 bu\u0148ky vykazuj\u00ED vy\u0161\u0161\u00ED \u00FArove\u0148 sign\u00E1lu Rho/ROCK spole\u010Dn\u011B se zv\u00FD\u0161enou dynamikou cytoskeletu a zv\u00FD\u0161enou ta\u017Enou silou vodic\u00ED lamely. Ukazuje se tedy, \u017Ee i bu\u0148ky mesenchym\u00E1ln\u00EDho p\u016Fvodu jsou schopny am\u00E9boidn\u00EDho pohybu, kter\u00FD je pro mesenchym netypick\u00FD, v z\u00E1vislosti na sign\u00E1lu p\u0159es Rho/ROCK."@cs . "11"^^ . . . "Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces" . "Vesel\u00FD, Pavel" . "6" . . "12"^^ . "Rosel, D." . "Molecular Cancer Research" . "000260017800003" . . . "RIV/68378050:_____/08:00318326" . . "Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces"@en . "1541-7786" . "Raupach, C." . . "Fabry, B." . "RIV/68378050:_____/08:00318326!RIV09-AV0-68378050" . . "P\u00E1nkov\u00E1, D." . "P(GA301/06/1147), Z(AV0Z50520514), Z(MSM0021620858)" . "[2321C90290C1]" . . "Highly metastatic and nonmetastatic cells were compared in the level of Rho/ROCK signaling. The metastatic cells exhibited up-regulation of this signaling, which leads to increased ivasion, increased cytoskeletal dynamis, and increased tractions at the leading edge of the cells. Even the cells of mesenchymal origin can use the ameboid mode of invasion in dependence on the Rho/ROCK signalling."@en . "Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces"@en . . "Bicanova, K." . "Regulace sign\u00E1lu Rho/ROCK v sarkomov\u00FDch bu\u0148k\u00E1ch \u0159\u00EDd\u00ED invazi a vytv\u00E1\u0159en\u00ED v\u00FDb\u011B\u017Ek\u016F"@cs . . . "9" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Regulace sign\u00E1lu Rho/ROCK v sarkomov\u00FDch bu\u0148k\u00E1ch \u0159\u00EDd\u00ED invazi a vytv\u00E1\u0159en\u00ED v\u00FDb\u011B\u017Ek\u016F"@cs . "Zitterbart, D. P." . "Highly metastatic and nonmetastatic cells were compared in the level of Rho/ROCK signaling. The metastatic cells exhibited up-regulation of this signaling, which leads to increased ivasion, increased cytoskeletal dynamis, and increased tractions at the leading edge of the cells. Even the cells of mesenchymal origin can use the ameboid mode of invasion in dependence on the Rho/ROCK signalling." . . "Folk, P." . "Kollmannsberger, P." . . . "Tolde, O." . . "Mierke, C. T." .