. "Konjug\u00E1ty porfyritu se \u017Elu\u010Dov\u00FDmi kyselinami: od rozpozn\u00E1v\u00E1n\u00ED sacharid\u016F v roztoku k selektivn\u00ED fluorescen\u010Dn\u00ED detekci v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch"@cs . "Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection" . . "Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection" . . "Pou\u010Dkov\u00E1, P." . . . . "1"^^ . "Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection"@en . . . . . "Konjug\u00E1ty porfyritu se \u017Elu\u010Dov\u00FDmi kyselinami: od rozpozn\u00E1v\u00E1n\u00ED sacharid\u016F v roztoku k selektivn\u00ED fluorescen\u010Dn\u00ED detekci v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch"@cs . "387665" . "This study describes the preparation and use of conjugates of porphyrins and bile acids as ligands binding to tumor-expressed saccharides. It was shown by fluorescence microscopy that they are preferentially taken up by transformed (tumor) cells. When exposed to the light of the appropriate wavelength, the photosensitizing activity of the porphyrin core results in the cascade of events leading to apoptosis and/or necrosis of tumor cells. Moreover, bile acid-porphyrin conjugates were used for selective ablation of tumors by photodynamic therapy. Both in vivo and in vitro studies demonstrated high potential of these compounds for use in targeted photodynamic therapy."@en . "RIV/68378050:_____/08:00314797!RIV09-AV0-68378050" . "Studie je zam\u011B\u0159ena na p\u0159\u00EDpravu a pou\u017Eit\u00ED konjug\u00E1t\u016F porfyrin\u016F se \u017Elu\u010Dov\u00FDmi kyselinami jako ligand\u016F pro sacharidy n\u00E1dorov\u00FDch bun\u011Bk. V\u00FDsledky fluorescen\u010Dn\u00ED mikroskopie potvrzuj\u00ED, \u017Ee tyto konjug\u00E1ty jsou p\u0159ednostn\u011B p\u0159ij\u00EDm\u00E1ny transformovan\u00FDmi (n\u00E1dorov\u00FDmi) bu\u0148kami. Pokud jsou n\u00E1sledn\u011B vystaveny sv\u011Btlu pat\u0159i\u010Dn\u00E9 vlnov\u00E9 d\u00E9lky, fotosensitivn\u00ED aktivita porfyrinov\u00E9ho j\u00E1dra m\u00E1 za n\u00E1sledek sled ud\u00E1lost\u00ED, kter\u00E9 vedou k apopt\u00F3ze nebo nekr\u00F3ze n\u00E1dorov\u00FDch bun\u011Bk. Nav\u00EDc lze konjug\u00E1ty \u017Elu\u010Dov\u00E1 kyselina-porfyrin pou\u017E\u00EDt k selektivn\u00EDmu odstran\u011Bn\u00ED n\u00E1dor\u016F pomoc\u00ED fotodynamick\u00E9 terapie. Potenci\u00E1l t\u011Bchto l\u00E1tek v c\u00EDlen\u00E9 fotodynamick\u00E9 terapii byl demonstrov\u00E1n jak in vitro tak in vivo studiemi."@cs . . "RIV/68378050:_____/08:00314797" . "Organic & Biomolecular Chemistry" . "Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection"@en . . "6" . "This study describes the preparation and use of conjugates of porphyrins and bile acids as ligands binding to tumor-expressed saccharides. It was shown by fluorescence microscopy that they are preferentially taken up by transformed (tumor) cells. When exposed to the light of the appropriate wavelength, the photosensitizing activity of the porphyrin core results in the cascade of events leading to apoptosis and/or necrosis of tumor cells. Moreover, bile acid-porphyrin conjugates were used for selective ablation of tumors by photodynamic therapy. Both in vivo and in vitro studies demonstrated high potential of these compounds for use in targeted photodynamic therapy." . . "Sievanen, E." . "Kr\u00E1l, V." . . "[8271AD5247E5]" . "7"^^ . . "porphyrin-bile acid conjugates; apoptosis; photodynamic therapy"@en . "Kej\u00EDk, Z." . "000255062300005" . "5"^^ . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Kr\u00E1lov\u00E1, Jarmila" . . "P(GA203/06/1038), P(LC06077), P(LC512), Z(AV0Z50520514), Z(MSM6046137307)" . "Kolehmainen, E." . "1477-0520" . . . . "Koivukorpi, J." . "9" .