. "Trachtulec, Zden\u011Bk" . . "Gregorov\u00E1, So\u0148a" . "haplotype; hybrid sterility"@en . . . "Strong linkage disequilibrium among classical laboratory (CL) strains represents an obstacle in the haplotype mapping of mouse quantitative trait loci (QTL). To determine the potential of wild-derived (WD) mouse strains for fine QTL mapping, we constructed a haplotype map of a 250-kb region of the t-complex on Chromosome 17 containing the Hybrid sterility 1 (Hst1) gene. We resequenced 33 loci from up to 80 chromosomes of 5 mouse (sub)species. Trans-species single-nucleotide polymorphisms (SNPs) were rare between Mus m. musculus (Mmmu) and Mus m. domesticus (Mmd). The haplotypes in Mmmu, Mmd, and t-chromosomes differed and thus should not be combined for haplotype mapping. Only a subset of SNPs and rearrangements found in CL strains were useful for haplotype mapping in wild Mmd. The largest Mmd haplotype block contained 3 genes of a highly conserved synteny. The Mmd haplotype blocks were tens of kb, suggesting that the WD Mmd strains are suitable for fine interval-specific mapping."@en . "P(1M0520), P(GA301/05/0738), P(IAA5052406), Z(AV0Z50520514)" . . . "6"^^ . "Vl\u010Dek, \u010Cestm\u00EDr" . "Strong linkage disequilibrium among classical laboratory (CL) strains represents an obstacle in the haplotype mapping of mouse quantitative trait loci (QTL). To determine the potential of wild-derived (WD) mouse strains for fine QTL mapping, we constructed a haplotype map of a 250-kb region of the t-complex on Chromosome 17 containing the Hybrid sterility 1 (Hst1) gene. We resequenced 33 loci from up to 80 chromosomes of 5 mouse (sub)species. Trans-species single-nucleotide polymorphisms (SNPs) were rare between Mus m. musculus (Mmmu) and Mus m. domesticus (Mmd). The haplotypes in Mmmu, Mmd, and t-chromosomes differed and thus should not be combined for haplotype mapping. Only a subset of SNPs and rearrangements found in CL strains were useful for haplotype mapping in wild Mmd. The largest Mmd haplotype block contained 3 genes of a highly conserved synteny. The Mmd haplotype blocks were tens of kb, suggesting that the WD Mmd strains are suitable for fine interval-specific mapping." . . "Fotopulosov\u00E1, Vladana" . . "Jemn\u00E1 haplotypov\u00E1 struktura oblasti chromosomu 17 u laboratorn\u00ED a divok\u00E9 my\u0161i"@cs . "3" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse" . . . "6"^^ . "Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse"@en . . "P\u0159i haplotypov\u00E9m mapov\u00E1n\u00ED my\u0161\u00EDch kvantitativn\u00EDch znak\u016F pomoc\u00ED klasick\u00FDch laboratorn\u00EDch kmen\u016F (CL) je p\u0159ek\u00E1\u017Ekou siln\u00E1 vazebn\u00E1 nerovnov\u00E1ha. Zkoumali jsme proto potenci\u00E1l my\u0161\u00EDch kmen\u016F recentn\u011B odvozen\u00FDch z divok\u00FDch my\u0161\u00ED (WD). Zkonstruovali jsme haplotypovou mapu oblasti o velikosti 250 kb z t-komplexu na chromosomu 17. Tato oblast obsahuje gen Hybrid sterility 1 (Hst1). Resekvenovali jsme 33 lokus\u016F z a\u017E 80 chromosom\u016F p\u011Bti my\u0161\u00EDch (pod)druh\u016F. Trans-specia\u010Dn\u00ED jednonukleotidov\u00E9 polymorfismy (SNP) mezi Mus m. musculus (Mmmu) a Mus m. domesticus (Mmd) byly vz\u00E1cn\u00E9. Haplotypy v Mmmu, Mmd a t-chromosomech se li\u0161ily, a nem\u011Bly by proto b\u00FDt kombinov\u00E1ny p\u0159i haplotypov\u00E9m mapov\u00E1n\u00ED. Pouze \u010D\u00E1st SNP\u016F a p\u0159eskup\u016F DNA nalezen\u00FDch v CL kmenech byla pou\u017Eiteln\u00E1 pro haplotypov\u00E9 mapov\u00E1n\u00ED v Mmd. Nejv\u011Bt\u0161\u00ED haplotypov\u00FD blok u Mmd pokr\u00FDval 3 geny konzervovan\u00E9 syntenie. Haplotypov\u00E9 bloky u Mmd byly dlouh\u00E9 des\u00EDtky kb, co\u017E ukazuje, \u017Ee WD Mmd kmeny jsou vhodn\u00E9 pro jemn\u00E9 intervalov\u00E9 mapov\u00E1n\u00ED."@cs . "368055" . "Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse" . "8"^^ . . . "RIV/68378050:_____/08:00306626!RIV09-AV0-68378050" . "Forejt, Ji\u0159\u00ED" . . "000254921600056" . "[4CC425B822FB]" . . . "178" . "Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse"@en . . "0016-6731" . . . "Mihola, Ond\u0159ej" . "Jemn\u00E1 haplotypov\u00E1 struktura oblasti chromosomu 17 u laboratorn\u00ED a divok\u00E9 my\u0161i"@cs . . . . "Genetics" . . "RIV/68378050:_____/08:00306626" .