"Denzel, A." . "9" . "Mack, M." . "The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis."@en . . . "11"^^ . . "Plach\u00FD, Ji\u0159\u00ED" . "Niedermeier, M." . . "[6DD9F0D9FB88]" . . "arthritis; CCR2; monocytes"@en . "Br\u00FChl, H." . . . "2975;2985" . "RIV/68378050:_____/07:00097943!RIV08-AV0-68378050" . "C\u00EDlen\u00ED Gr-1+,CCR2+ monocyt\u016F u arthritidy vyvolan\u00E9 kolagenem"@cs . "Arthritis and Rheumatism" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "56" . "Kunz-Schughart, L." . . "Cihak, J." . "0004-3591" . "Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis" . . "C\u00EDlen\u00ED Gr-1+,CCR2+ monocyt\u016F u arthritidy vyvolan\u00E9 kolagenem"@cs . "Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis"@en . "Gomez, M. R." . . . "Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis" . "454163" . "1"^^ . . "Talke, Y." . "Stangassinger, M." . "RIV/68378050:_____/07:00097943" . . "Luckow, B." . "The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis." . "Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis"@en . "11"^^ . "Chemokinov\u00FD receptor CCR2 je vysoce exprimov\u00E1n na monocytech a zd\u00E1 se b\u00FDt slibn\u00FDm ter\u010Dem pro l\u00E9\u010Dbu reumatick\u00E9 arthritidy. Blokov\u00E1n\u00ED CCR2 monoklon\u00E1ln\u00ED protil\u00E1tkou p\u0159i arthritid\u011B vyvolan\u00E9 kolagenem v\u0161ak vede k masivn\u00EDmu zhor\u0161en\u00ED t\u00E9to choroby. V t\u00E9to studii jsme sledovali, pro\u010D protil\u00E1tky CCR2+ maj\u00ED proz\u00E1n\u011Btliv\u00E9 \u00FA\u010Dinky, jak se t\u011Bmto \u00FA\u010Dink\u016Fm lze vyhnout a zda jsou monocyty CCR2+ dobr\u00FDmi ter\u010Di pro l\u00E9\u010Dbu arthritidy."@cs . . . "Z(AV0Z50520514)" .